FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000373375> ?p ?o ?g. }

• W2000373375 endingPage "230" @default.
• W2000373375 startingPage "219" @default.
• W2000373375 abstract "In the present study, we have used DNA microarray and quantitative real-time PCR analysis to examine the transcriptional changes that occur in response to cellular depletion of the yeast acyl-CoA-binding protein, Acb1p. Depletion of Acb1p resulted in the differential expression of genes encoding proteins involved in fatty acid and phospholipid synthesis (e.g. FAS1, FAS2, ACC1, OLE1, INO1 and OPI3), glycolysis and glycerol metabolism (e.g. GPD1 and TDH1), ion transport and uptake (e.g. ITR1 and HNM1) and stress response (e.g. HSP12, DDR2 and CTT1). In the present study, we show that transcription of the INO1 gene, which encodes inositol-3-phosphate synthase, cannot be fully repressed by inositol and choline, and UASINO1 (inositol-sensitive upstream activating sequence)-driven transcription is enhanced in Acb1p-depleted cells. In addition, the reduction in inositol-mediated repression of INO1 transcription observed after depletion of Acb1p appeared to be independent of the transcriptional repressor, Opi1p. We also demonstrated that INO1 and OPI3 expression can be normalized in Acb1p-depleted cells by the addition of high concentrations of exogenous fatty acids, or by the overexpression of FAS1 or ACC1. Together, these findings revealed an Acb1p-dependent connection between fatty acid metabolism and transcriptional regulation of phospholipid biosynthesis in yeast. Finally, expression of an Acb1p mutant which is unable to bind acyl-CoA esters could not normalize the transcriptional changes caused by Acb1p depletion. This strongly implied that gene expression is modulated either by the Acb1p–acyl-CoA ester complex directly or by its ability to donate acyl-CoA esters to utilizing systems." @default.
• W2000373375 created "2016-06-24" @default.
• W2000373375 creator A5012580074 @default.
• W2000373375 creator A5041757990 @default.
• W2000373375 creator A5078976364 @default.
• W2000373375 creator A5079564960 @default.
• W2000373375 date "2007-09-25" @default.
• W2000373375 modified "2023-10-15" @default.
• W2000373375 title "Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in <i>Saccharomyces cerevisiae</i>" @default.
• W2000373375 cites W1497947649 @default.
• W2000373375 cites W1566478858 @default.
• W2000373375 cites W1601603816 @default.
• W2000373375 cites W1760626668 @default.
• W2000373375 cites W1763805809 @default.
• W2000373375 cites W1803320470 @default.
• W2000373375 cites W1957498445 @default.
• W2000373375 cites W1966072209 @default.
• W2000373375 cites W1969026949 @default.
• W2000373375 cites W1970641718 @default.
• W2000373375 cites W1974149821 @default.
• W2000373375 cites W1988206655 @default.
• W2000373375 cites W1990400035 @default.
• W2000373375 cites W2002173318 @default.
• W2000373375 cites W2009068619 @default.
• W2000373375 cites W2011764708 @default.
• W2000373375 cites W2029642537 @default.
• W2000373375 cites W2034190304 @default.
• W2000373375 cites W2051373244 @default.
• W2000373375 cites W2052586663 @default.
• W2000373375 cites W2059867106 @default.
• W2000373375 cites W2063828850 @default.
• W2000373375 cites W2066909405 @default.
• W2000373375 cites W2075893100 @default.
• W2000373375 cites W2077446662 @default.
• W2000373375 cites W2082442877 @default.
• W2000373375 cites W2083727519 @default.
• W2000373375 cites W2085085319 @default.
• W2000373375 cites W2088747879 @default.
• W2000373375 cites W2091663340 @default.
• W2000373375 cites W2096366162 @default.
• W2000373375 cites W2099239388 @default.
• W2000373375 cites W2102940990 @default.
• W2000373375 cites W2105821361 @default.
• W2000373375 cites W2105976996 @default.
• W2000373375 cites W2107277218 @default.
• W2000373375 cites W2120295812 @default.
• W2000373375 cites W2120679044 @default.
• W2000373375 cites W2134904267 @default.
• W2000373375 cites W2139002144 @default.
• W2000373375 cites W2151373469 @default.
• W2000373375 cites W2162070972 @default.
• W2000373375 cites W2164031736 @default.
• W2000373375 cites W2166868058 @default.
• W2000373375 cites W2184043735 @default.
• W2000373375 cites W2192080449 @default.
• W2000373375 cites W2242477415 @default.
• W2000373375 cites W2259678263 @default.
• W2000373375 cites W2271727959 @default.
• W2000373375 cites W2411074224 @default.
• W2000373375 cites W4240065971 @default.
• W2000373375 cites W4244410612 @default.
• W2000373375 doi "https://doi.org/10.1042/bj20070315" @default.
• W2000373375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2049021" @default.
• W2000373375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17593018" @default.
• W2000373375 hasPublicationYear "2007" @default.
• W2000373375 type Work @default.
• W2000373375 sameAs 2000373375 @default.
• W2000373375 citedByCount "46" @default.
• W2000373375 countsByYear W20003733752012 @default.
• W2000373375 countsByYear W20003733752013 @default.
• W2000373375 countsByYear W20003733752014 @default.
• W2000373375 countsByYear W20003733752015 @default.
• W2000373375 countsByYear W20003733752016 @default.
• W2000373375 countsByYear W20003733752017 @default.
• W2000373375 countsByYear W20003733752018 @default.
• W2000373375 countsByYear W20003733752019 @default.
• W2000373375 countsByYear W20003733752021 @default.
• W2000373375 countsByYear W20003733752022 @default.
• W2000373375 countsByYear W20003733752023 @default.
• W2000373375 crossrefType "journal-article" @default.
• W2000373375 hasAuthorship W2000373375A5012580074 @default.
• W2000373375 hasAuthorship W2000373375A5041757990 @default.
• W2000373375 hasAuthorship W2000373375A5078976364 @default.
• W2000373375 hasAuthorship W2000373375A5079564960 @default.
• W2000373375 hasBestOaLocation W20003733752 @default.
• W2000373375 hasConcept C101762097 @default.
• W2000373375 hasConcept C104317684 @default.
• W2000373375 hasConcept C138885662 @default.
• W2000373375 hasConcept C150194340 @default.
• W2000373375 hasConcept C158448853 @default.
• W2000373375 hasConcept C170493617 @default.
• W2000373375 hasConcept C179926584 @default.
• W2000373375 hasConcept C192245184 @default.
• W2000373375 hasConcept C27153228 @default.
• W2000373375 hasConcept C2776991927 @default.
• W2000373375 hasConcept C2777427919 @default.
• W2000373375 hasConcept C2777576037 @default.
• W2000373375 hasConcept C2778918659 @default.

• next