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- W2000373465 abstract "Locally produced peptide hormones kinins, such as bradykinin, are thought to oppose many of the prohypertensive actions of the renin-angiotensin-aldosterone system. In the kidney, bradykinin, via stimulation of B2 receptors (B2R), favors natriuresis mostly due to the inhibition of tubular Na reabsorption. Recent experimental evidence identifies the epithelial Na channel (ENaC) as a key end effector of bradykinin actions in the distal tubular segments. The focus of this review is the physiological relevance and molecular details of the bradykinin signal to ENaC.The recent epidemiological GenSalt study demonstrated that genetic variants of the gene encoding B2R show significant associations with the salt sensitivity of blood pressure. Bradykinin was shown to have an inhibitory effect on the distal nephron sodium transport via stimulation of B2 receptor-phospholipase C (B2R-PLC) cascade to decrease ENaC open probability. Genetic ablation of bradykinin receptors in mice led to an augmented ENaC function, particularly during elevated sodium intake, likely contributing to the salt-sensitive hypertensive phenotype. Furthermore, augmentation of bradykinin signaling in the distal nephron was demonstrated to be an important component of the natriuretic and antihypertensive effects of angiotensin converting enzyme inhibition.Salt-sensitive inhibition of ENaC activity by bradykinin greatly advances our understanding of the molecular mechanisms that are responsible for shutting down distal tubule sodium reabsorption during volume expanded conditions to avoid salt-sensitive hypertension." @default.
- W2000373465 created "2016-06-24" @default.
- W2000373465 creator A5014657118 @default.
- W2000373465 creator A5025348068 @default.
- W2000373465 creator A5034674216 @default.
- W2000373465 date "2014-03-01" @default.
- W2000373465 modified "2023-10-16" @default.
- W2000373465 title "Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling" @default.
- W2000373465 cites W1480141326 @default.
- W2000373465 cites W1507291865 @default.
- W2000373465 cites W1550905784 @default.
- W2000373465 cites W1681499960 @default.
- W2000373465 cites W1963865377 @default.
- W2000373465 cites W1966102491 @default.
- W2000373465 cites W1966110783 @default.
- W2000373465 cites W1969275919 @default.
- W2000373465 cites W1974041902 @default.
- W2000373465 cites W1975282060 @default.
- W2000373465 cites W1978869489 @default.
- W2000373465 cites W1981631360 @default.
- W2000373465 cites W1982076095 @default.
- W2000373465 cites W1983360201 @default.
- W2000373465 cites W1983524637 @default.
- W2000373465 cites W1985546355 @default.
- W2000373465 cites W1987325295 @default.
- W2000373465 cites W1993487455 @default.
- W2000373465 cites W1994482946 @default.
- W2000373465 cites W1996588710 @default.
- W2000373465 cites W2000096521 @default.
- W2000373465 cites W2001207560 @default.
- W2000373465 cites W2002563649 @default.
- W2000373465 cites W2004903527 @default.
- W2000373465 cites W2004992040 @default.
- W2000373465 cites W2010558902 @default.
- W2000373465 cites W2012557844 @default.
- W2000373465 cites W2020056111 @default.
- W2000373465 cites W2023715246 @default.
- W2000373465 cites W2026857235 @default.
- W2000373465 cites W2028982762 @default.
- W2000373465 cites W2032766842 @default.
- W2000373465 cites W2033244057 @default.
- W2000373465 cites W2034800607 @default.
- W2000373465 cites W2041945983 @default.
- W2000373465 cites W2049276949 @default.
- W2000373465 cites W2053292076 @default.
- W2000373465 cites W2060462859 @default.
- W2000373465 cites W2062492730 @default.
- W2000373465 cites W2066418121 @default.
- W2000373465 cites W2068347291 @default.
- W2000373465 cites W2072201219 @default.
- W2000373465 cites W2073881942 @default.
- W2000373465 cites W2083914594 @default.
- W2000373465 cites W2084301255 @default.
- W2000373465 cites W2088883717 @default.
- W2000373465 cites W2099114143 @default.
- W2000373465 cites W2103808233 @default.
- W2000373465 cites W2108616699 @default.
- W2000373465 cites W2112874026 @default.
- W2000373465 cites W2114783598 @default.
- W2000373465 cites W2116717490 @default.
- W2000373465 cites W2117214491 @default.
- W2000373465 cites W2117522130 @default.
- W2000373465 cites W2119821289 @default.
- W2000373465 cites W2124663880 @default.
- W2000373465 cites W2128413998 @default.
- W2000373465 cites W2132128862 @default.
- W2000373465 cites W2139662912 @default.
- W2000373465 cites W2140853270 @default.
- W2000373465 cites W2147819663 @default.
- W2000373465 cites W2155510119 @default.
- W2000373465 cites W2157819909 @default.
- W2000373465 cites W2157888026 @default.
- W2000373465 cites W2159274426 @default.
- W2000373465 cites W2161832913 @default.
- W2000373465 cites W2162782596 @default.
- W2000373465 cites W2164145533 @default.
- W2000373465 cites W2166629377 @default.
- W2000373465 cites W2169650170 @default.
- W2000373465 cites W2170374866 @default.
- W2000373465 cites W2265117136 @default.
- W2000373465 cites W2319658883 @default.
- W2000373465 cites W2320655060 @default.
- W2000373465 cites W2405573211 @default.
- W2000373465 cites W4251679311 @default.
- W2000373465 doi "https://doi.org/10.1097/01.mnh.0000441053.81339.61" @default.
- W2000373465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114036" @default.
- W2000373465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24378775" @default.
- W2000373465 hasPublicationYear "2014" @default.
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