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• W2000373946 abstract "To determine if HIV-infected patients with no detectable serum antibodies to p24 are producing antibodies to p24 (anti-p24), blood was obtained from 49 HIV-infected patients at various stages of infection. Serum p24 antigen levels were measured and peripheral blood mononuclear cells were cultured for 1 week without mitogenic stimulation. The presence of anti-p24 in culture supernatants and sera was determined by radioimmunoprecipitation assays. Cells from 89% of the patients who had anti-p24 in their sera spontaneously synthesized anti-p24 in vitro. Similarly, cells from 83% of the HIV-infected patients who had no detectable anti-p24 in their sera spontaneously produced anti-p24 in vitro. Thus the absence of anti-p24 in serum did not reflect suppression in the ability of patients' cells to synthesize and secrete antibodies to p24. However, cells from patients whose sera contained anti-p24 spontaneously synthesized more anti-p24 than did cells from patients whose sera lacked anti-p24, suggesting that these two groups of patients may represent individuals with inherently high or low responses to p24 epitopes, respectively." @default.
• W2000373946 created "2016-06-24" @default.
• W2000373946 creator A5040704124 @default.
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• W2000373946 date "1992-01-01" @default.
• W2000373946 modified "2023-09-26" @default.
• W2000373946 title "p24 Antibody Production in p24 Antibody-Negative HIV-Infected Subjects" @default.
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• W2000373946 doi "https://doi.org/10.1089/vim.1992.5.123" @default.
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