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- W2000375401 abstract "The most frequent cancers in industrialized societies are derived from epithelia of the gastrointestinal and urogenital tract, as well as of mammary ducts and bronchi. The failure of new early detection methods and improved surgical therapy to decrease the mortality caused by these tumors may be due to the presence of early micrometastatic tumor cell spread, which is usually missed by conventional tumor staging. Analysis of peripheral blood would be obviously the most convenient way to detect hematogeneous tumor cell dissemination. However, the frequency of tumor cells appears to be even lower in blood than in bone marrow. Therefore, we concentrated our work to the detection of bone marrow-derived micrometastatic cancer cells. The biological relevance of circulating tumor cells is unclear since experimental data indicate that most of them do not settle in secondary organs. Nevertheless, tumor cells are more readily found in leukapheresis products used as an increasingly important source of hematopoietic stem cells. Since autologous peripheral stem cell transplantation is a valuable supportive measure which allows the application of high-dose chemotherapy in patients with solid tumors, the detection and elimination of tumor cells in the transplant is of obvious clinical relevance. The present review focuses on diagnostic approaches to identify patients with minimal residual epithelial cancer." @default.
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- W2000375401 date "1999-01-01" @default.
- W2000375401 modified "2023-09-25" @default.
- W2000375401 title "Detection of Disseminated Epithelial Tumor Cells: Methods and Clinical Implications" @default.
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- W2000375401 doi "https://doi.org/10.1159/000053471" @default.
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