FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000375438> ?p ?o ?g. }

• W2000375438 endingPage "321" @default.
• W2000375438 startingPage "311" @default.
• W2000375438 abstract "In a recent study using Wistar rats, the serotonergic 5-HT2 receptor antagonists ketanserin and risperidone reduced the disruptive effects of the noncompetitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine on prepulse inhibition (PPI), suggesting that there is an interaction between serotonin and glutamate in the modulation of PPI. In contrast, studies using the noncompetitive NMDA antagonist phencyclidine (PCP) in Sprague–Dawley rats found no effect with 5-HT2 antagonists. To test the hypothesis that strain differences might explain the discrepancy in these findings, risperidone was tested for its ability to reduce the PPI-disruptive effects of dizocilpine in Wistar and Sprague–Dawley rats. Furthermore, to determine which serotonergic receptor subtype may mediate this effect, the 5-HT2A receptor antagonist M100907 (formerly MDL 100,907) and the 5-HT2C receptor antagonist SDZ SER 082 were tested against dizocilpine. Recent studies have found that the PPI-disruptive effects of PCP are reduced by the α1 adrenergic receptor antagonist prazosin. Furthermore, the α1 receptor agonist cirazoline disrupts PPI. As risperidone and M100907 have affinity at the α1 receptor, a final study examined whether M100907 would block the effects of cirazoline on PPI. Risperidone partially, but nonsignificantly, reduced the effects of dizocilpine in Wistar rats, although this effect was smaller than previously reported. Consistent with previous studies, risperidone did not alter the effects of dizocilpine in Sprague–Dawley rats. Most importantly, M100907 pretreatment fully blocked the effect of dizocilpine in both strains; whereas SDZ SER 082 had no effect. M100907 had no influence on PPI by itself and did not reduce the effects of cirazoline on PPI. These studies confirm the suggestion that serotonin and glutamate interact in modulating PPI and indicate that the 5-HT2A receptor subtype mediates this interaction. Furthermore, this interaction occurs in at least two rat strains. [Neuropsychopharmacology 20:311–321, 1999]" @default.
• W2000375438 created "2016-06-24" @default.
• W2000375438 creator A5038609766 @default.
• W2000375438 date "1999-04-01" @default.
• W2000375438 modified "2023-10-11" @default.
• W2000375438 title "M100907, a Serotonin 5-HT2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats" @default.
• W2000375438 cites W1907720276 @default.
• W2000375438 cites W1972895831 @default.
• W2000375438 cites W1974696185 @default.
• W2000375438 cites W1979700184 @default.
• W2000375438 cites W1982931433 @default.
• W2000375438 cites W1986859027 @default.
• W2000375438 cites W1990414759 @default.
• W2000375438 cites W1990888488 @default.
• W2000375438 cites W1991964519 @default.
• W2000375438 cites W1994584257 @default.
• W2000375438 cites W1995152135 @default.
• W2000375438 cites W1998141074 @default.
• W2000375438 cites W2000689909 @default.
• W2000375438 cites W2007011615 @default.
• W2000375438 cites W2022196036 @default.
• W2000375438 cites W2030247720 @default.
• W2000375438 cites W2031678734 @default.
• W2000375438 cites W2034967655 @default.
• W2000375438 cites W2042676846 @default.
• W2000375438 cites W2045216666 @default.
• W2000375438 cites W2045505416 @default.
• W2000375438 cites W2054789315 @default.
• W2000375438 cites W2055941349 @default.
• W2000375438 cites W2056438092 @default.
• W2000375438 cites W2060884332 @default.
• W2000375438 cites W2070605348 @default.
• W2000375438 cites W2084253035 @default.
• W2000375438 cites W2086100108 @default.
• W2000375438 cites W2096824787 @default.
• W2000375438 cites W2097759310 @default.
• W2000375438 cites W2107814054 @default.
• W2000375438 cites W2121264019 @default.
• W2000375438 cites W2165311316 @default.
• W2000375438 cites W2208270236 @default.
• W2000375438 cites W2329891286 @default.
• W2000375438 doi "https://doi.org/10.1016/s0893-133x(98)00072-4" @default.
• W2000375438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10088132" @default.
• W2000375438 hasPublicationYear "1999" @default.
• W2000375438 type Work @default.
• W2000375438 sameAs 2000375438 @default.
• W2000375438 citedByCount "150" @default.
• W2000375438 countsByYear W20003754382012 @default.
• W2000375438 countsByYear W20003754382013 @default.
• W2000375438 countsByYear W20003754382014 @default.
• W2000375438 countsByYear W20003754382015 @default.
• W2000375438 countsByYear W20003754382016 @default.
• W2000375438 countsByYear W20003754382017 @default.
• W2000375438 countsByYear W20003754382018 @default.
• W2000375438 countsByYear W20003754382019 @default.
• W2000375438 countsByYear W20003754382020 @default.
• W2000375438 countsByYear W20003754382021 @default.
• W2000375438 countsByYear W20003754382022 @default.
• W2000375438 countsByYear W20003754382023 @default.
• W2000375438 crossrefType "journal-article" @default.
• W2000375438 hasAuthorship W2000375438A5038609766 @default.
• W2000375438 hasBestOaLocation W20003754381 @default.
• W2000375438 hasConcept C118552586 @default.
• W2000375438 hasConcept C141421786 @default.
• W2000375438 hasConcept C15744967 @default.
• W2000375438 hasConcept C170493617 @default.
• W2000375438 hasConcept C185592680 @default.
• W2000375438 hasConcept C2775864247 @default.
• W2000375438 hasConcept C2776412080 @default.
• W2000375438 hasConcept C2776885963 @default.
• W2000375438 hasConcept C2777785214 @default.
• W2000375438 hasConcept C2777836312 @default.
• W2000375438 hasConcept C2778122271 @default.
• W2000375438 hasConcept C2778851735 @default.
• W2000375438 hasConcept C2778938600 @default.
• W2000375438 hasConcept C37000724 @default.
• W2000375438 hasConcept C53910766 @default.
• W2000375438 hasConcept C55493867 @default.
• W2000375438 hasConcept C67018056 @default.
• W2000375438 hasConcept C71924100 @default.
• W2000375438 hasConcept C86811712 @default.
• W2000375438 hasConcept C98274493 @default.
• W2000375438 hasConceptScore W2000375438C118552586 @default.
• W2000375438 hasConceptScore W2000375438C141421786 @default.
• W2000375438 hasConceptScore W2000375438C15744967 @default.
• W2000375438 hasConceptScore W2000375438C170493617 @default.
• W2000375438 hasConceptScore W2000375438C185592680 @default.
• W2000375438 hasConceptScore W2000375438C2775864247 @default.
• W2000375438 hasConceptScore W2000375438C2776412080 @default.
• W2000375438 hasConceptScore W2000375438C2776885963 @default.
• W2000375438 hasConceptScore W2000375438C2777785214 @default.
• W2000375438 hasConceptScore W2000375438C2777836312 @default.
• W2000375438 hasConceptScore W2000375438C2778122271 @default.
• W2000375438 hasConceptScore W2000375438C2778851735 @default.
• W2000375438 hasConceptScore W2000375438C2778938600 @default.
• W2000375438 hasConceptScore W2000375438C37000724 @default.
• W2000375438 hasConceptScore W2000375438C53910766 @default.
• W2000375438 hasConceptScore W2000375438C55493867 @default.

• next