FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000376263> ?p ?o ?g. }

• W2000376263 endingPage "8" @default.
• W2000376263 startingPage "1" @default.
• W2000376263 abstract "Ubiquitous tissue transglutaminase (tTG) is one member of the large transglutaminase (TG) family, which catalyze posttranslational modification of proteins by establishing epsilon(gamma-glutamyl)lysine cross-linking and/or covalent incorporation of polyamines. The unique characteristics of tTG include: (1) possessing both cross-linking activity and GTPase activity; (2) functioning as a G protein; and (3) participating in the signal transduction of alpha1-adrenergic receptor coupling. A growing body of literature suggests that increased tTG levels in the cytosolic or nuclear compartments contribute to the apoptotic process, and lines of evidence exist that nuclear translocation and cross-linking of transcriptional factor Sp1 may represent the underlying mechanisms of these proapoptotic effects of tTG. Our studies indicate that tTG GTPase activation may be responsible for enhanced hepatocyte proliferation, whereas, its tTGase activity may cause increased apoptosis. Moreover, it appears that tTG cross-linking activity contributes to hepatic fibrogenesis in animal models and in human liver disease. Understanding the roles of tTG in the pathogenesis of liver disease could facilitate the development of new treatment regimens." @default.
• W2000376263 created "2016-06-24" @default.
• W2000376263 creator A5007716183 @default.
• W2000376263 creator A5073686280 @default.
• W2000376263 date "2004-05-01" @default.
• W2000376263 modified "2023-09-23" @default.
• W2000376263 title "Tissue transglutaminase, a key enzyme involved in liver diseases" @default.
• W2000376263 cites W1514968181 @default.
• W2000376263 cites W1522062003 @default.
• W2000376263 cites W1533702935 @default.
• W2000376263 cites W1600746052 @default.
• W2000376263 cites W1606499176 @default.
• W2000376263 cites W1621124914 @default.
• W2000376263 cites W1964916595 @default.
• W2000376263 cites W1966141691 @default.
• W2000376263 cites W1973566033 @default.
• W2000376263 cites W1978498632 @default.
• W2000376263 cites W1984098305 @default.
• W2000376263 cites W1984332162 @default.
• W2000376263 cites W1986366555 @default.
• W2000376263 cites W1988931510 @default.
• W2000376263 cites W1989603835 @default.
• W2000376263 cites W1992006494 @default.
• W2000376263 cites W1995935153 @default.
• W2000376263 cites W2002663829 @default.
• W2000376263 cites W2007577954 @default.
• W2000376263 cites W2008547021 @default.
• W2000376263 cites W2011915496 @default.
• W2000376263 cites W2014161042 @default.
• W2000376263 cites W2015320012 @default.
• W2000376263 cites W2020463577 @default.
• W2000376263 cites W2027218428 @default.
• W2000376263 cites W2038847481 @default.
• W2000376263 cites W2042909802 @default.
• W2000376263 cites W2045255717 @default.
• W2000376263 cites W2049455477 @default.
• W2000376263 cites W2049684405 @default.
• W2000376263 cites W2051788484 @default.
• W2000376263 cites W2052366372 @default.
• W2000376263 cites W2053155552 @default.
• W2000376263 cites W2058146757 @default.
• W2000376263 cites W2060750433 @default.
• W2000376263 cites W2061413318 @default.
• W2000376263 cites W2063145932 @default.
• W2000376263 cites W2063708626 @default.
• W2000376263 cites W2067403820 @default.
• W2000376263 cites W2068629141 @default.
• W2000376263 cites W2073342372 @default.
• W2000376263 cites W2082814018 @default.
• W2000376263 cites W2102182448 @default.
• W2000376263 cites W2130094975 @default.
• W2000376263 cites W2142113094 @default.
• W2000376263 cites W2142783613 @default.
• W2000376263 cites W2147698913 @default.
• W2000376263 cites W2149300233 @default.
• W2000376263 cites W2154852917 @default.
• W2000376263 cites W2161261662 @default.
• W2000376263 cites W2188626138 @default.
• W2000376263 cites W2417845814 @default.
• W2000376263 cites W3015021354 @default.
• W2000376263 doi "https://doi.org/10.1016/j.hepres.2004.02.007" @default.
• W2000376263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15135339" @default.
• W2000376263 hasPublicationYear "2004" @default.
• W2000376263 type Work @default.
• W2000376263 sameAs 2000376263 @default.
• W2000376263 citedByCount "20" @default.
• W2000376263 countsByYear W20003762632012 @default.
• W2000376263 countsByYear W20003762632013 @default.
• W2000376263 countsByYear W20003762632016 @default.
• W2000376263 countsByYear W20003762632018 @default.
• W2000376263 countsByYear W20003762632021 @default.
• W2000376263 crossrefType "journal-article" @default.
• W2000376263 hasAuthorship W2000376263A5007716183 @default.
• W2000376263 hasAuthorship W2000376263A5073686280 @default.
• W2000376263 hasConcept C170493617 @default.
• W2000376263 hasConcept C178498320 @default.
• W2000376263 hasConcept C181199279 @default.
• W2000376263 hasConcept C190283241 @default.
• W2000376263 hasConcept C203014093 @default.
• W2000376263 hasConcept C207332259 @default.
• W2000376263 hasConcept C2780942790 @default.
• W2000376263 hasConcept C55493867 @default.
• W2000376263 hasConcept C62478195 @default.
• W2000376263 hasConcept C80631254 @default.
• W2000376263 hasConcept C85771745 @default.
• W2000376263 hasConcept C86803240 @default.
• W2000376263 hasConcept C95444343 @default.
• W2000376263 hasConceptScore W2000376263C170493617 @default.
• W2000376263 hasConceptScore W2000376263C178498320 @default.
• W2000376263 hasConceptScore W2000376263C181199279 @default.
• W2000376263 hasConceptScore W2000376263C190283241 @default.
• W2000376263 hasConceptScore W2000376263C203014093 @default.
• W2000376263 hasConceptScore W2000376263C207332259 @default.
• W2000376263 hasConceptScore W2000376263C2780942790 @default.
• W2000376263 hasConceptScore W2000376263C55493867 @default.
• W2000376263 hasConceptScore W2000376263C62478195 @default.
• W2000376263 hasConceptScore W2000376263C80631254 @default.
• W2000376263 hasConceptScore W2000376263C85771745 @default.

• next