FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000376321> ?p ?o ?g. }

• W2000376321 endingPage "829" @default.
• W2000376321 startingPage "822" @default.
• W2000376321 abstract "Aberrant sperm DNA methylation patterns, mainly in imprinted genes, have been associated with male subfertility and oligospermia. Here, we performed a genome-wide methylation analysis in sperm samples representing a wide range of semen parameters. Sperm DNA samples of 38 males attending a fertility centre were analysed with Illumina HumanMethylation27 BeadChips, which quantify methylation of >27 000 CpG sites in cis-regulatory regions of almost 15 000 genes. In an unsupervised analysis of methylation of all analysed sites, the patient samples clustered into a major and a minor group. The major group clustered with samples from normozoospermic healthy volunteers and, thus, may more closely resemble the normal situation. When correlating the clusters with semen and clinical parameters, the sperm counts were significantly different between groups with the minor group exhibiting sperm counts in the low normal range. A linear model identified almost 3000 CpGs with significant methylation differences between groups. Functional analysis revealed a broad gain of methylation in spermatogenesis-related genes and a loss of methylation in inflammation- and immune response-related genes. Quantitative bisulfite pyrosequencing validated differential methylation in three of five significant candidate genes on the array. Collectively, we identified a subgroup of sperm samples for assisted reproduction with sperm counts in the low normal range and broad methylation changes (affecting approximately 10% of analysed CpG sites) in specific pathways, most importantly spermatogenesis-related genes. We propose that epigenetic analysis can supplement traditional semen parameters and has the potential to provide new insights into the aetiology of male subfertility." @default.
• W2000376321 created "2016-06-24" @default.
• W2000376321 creator A5017474493 @default.
• W2000376321 creator A5026489964 @default.
• W2000376321 creator A5038382123 @default.
• W2000376321 creator A5046341399 @default.
• W2000376321 creator A5048402117 @default.
• W2000376321 creator A5052306361 @default.
• W2000376321 creator A5061168255 @default.
• W2000376321 creator A5064274797 @default.
• W2000376321 creator A5070610653 @default.
• W2000376321 creator A5077295007 @default.
• W2000376321 date "2013-08-28" @default.
• W2000376321 modified "2023-09-26" @default.
• W2000376321 title "Broad <scp>DNA</scp> methylation changes of spermatogenesis, inflammation and immune response‐related genes in a subgroup of sperm samples for assisted reproduction" @default.
• W2000376321 cites W1596459374 @default.
• W2000376321 cites W1821797507 @default.
• W2000376321 cites W1973250347 @default.
• W2000376321 cites W1989557513 @default.
• W2000376321 cites W1990195106 @default.
• W2000376321 cites W1992188147 @default.
• W2000376321 cites W2012603112 @default.
• W2000376321 cites W2016381774 @default.
• W2000376321 cites W2020350008 @default.
• W2000376321 cites W2023844789 @default.
• W2000376321 cites W2037818631 @default.
• W2000376321 cites W2047939916 @default.
• W2000376321 cites W2049720180 @default.
• W2000376321 cites W2056040742 @default.
• W2000376321 cites W2062970314 @default.
• W2000376321 cites W2063625595 @default.
• W2000376321 cites W2064801165 @default.
• W2000376321 cites W2066305483 @default.
• W2000376321 cites W2068227162 @default.
• W2000376321 cites W2080722280 @default.
• W2000376321 cites W2081098333 @default.
• W2000376321 cites W2081156152 @default.
• W2000376321 cites W2085858842 @default.
• W2000376321 cites W2087927055 @default.
• W2000376321 cites W2088341189 @default.
• W2000376321 cites W2092463855 @default.
• W2000376321 cites W2094942225 @default.
• W2000376321 cites W2102868331 @default.
• W2000376321 cites W2104843251 @default.
• W2000376321 cites W2106608030 @default.
• W2000376321 cites W2110065044 @default.
• W2000376321 cites W2118534883 @default.
• W2000376321 cites W2120212303 @default.
• W2000376321 cites W2123427245 @default.
• W2000376321 cites W2124603532 @default.
• W2000376321 cites W2131093877 @default.
• W2000376321 cites W2132751131 @default.
• W2000376321 cites W2137733809 @default.
• W2000376321 cites W2140954822 @default.
• W2000376321 cites W2142946845 @default.
• W2000376321 cites W2153523586 @default.
• W2000376321 cites W2162224252 @default.
• W2000376321 cites W2163130704 @default.
• W2000376321 cites W2163670586 @default.
• W2000376321 cites W2463686631 @default.
• W2000376321 doi "https://doi.org/10.1111/j.2047-2927.2013.00122.x" @default.
• W2000376321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4033565" @default.
• W2000376321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23996961" @default.
• W2000376321 hasPublicationYear "2013" @default.
• W2000376321 type Work @default.
• W2000376321 sameAs 2000376321 @default.
• W2000376321 citedByCount "37" @default.
• W2000376321 countsByYear W20003763212014 @default.
• W2000376321 countsByYear W20003763212015 @default.
• W2000376321 countsByYear W20003763212016 @default.
• W2000376321 countsByYear W20003763212017 @default.
• W2000376321 countsByYear W20003763212018 @default.
• W2000376321 countsByYear W20003763212019 @default.
• W2000376321 countsByYear W20003763212020 @default.
• W2000376321 countsByYear W20003763212021 @default.
• W2000376321 countsByYear W20003763212022 @default.
• W2000376321 countsByYear W20003763212023 @default.
• W2000376321 crossrefType "journal-article" @default.
• W2000376321 hasAuthorship W2000376321A5017474493 @default.
• W2000376321 hasAuthorship W2000376321A5026489964 @default.
• W2000376321 hasAuthorship W2000376321A5038382123 @default.
• W2000376321 hasAuthorship W2000376321A5046341399 @default.
• W2000376321 hasAuthorship W2000376321A5048402117 @default.
• W2000376321 hasAuthorship W2000376321A5052306361 @default.
• W2000376321 hasAuthorship W2000376321A5061168255 @default.
• W2000376321 hasAuthorship W2000376321A5064274797 @default.
• W2000376321 hasAuthorship W2000376321A5070610653 @default.
• W2000376321 hasAuthorship W2000376321A5077295007 @default.
• W2000376321 hasBestOaLocation W20003763211 @default.
• W2000376321 hasConcept C104317684 @default.
• W2000376321 hasConcept C123765429 @default.
• W2000376321 hasConcept C134018914 @default.
• W2000376321 hasConcept C140173407 @default.
• W2000376321 hasConcept C150194340 @default.
• W2000376321 hasConcept C154253233 @default.
• W2000376321 hasConcept C16685009 @default.
• W2000376321 hasConcept C190727270 @default.
• W2000376321 hasConcept C2777338322 @default.

• next