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- W2000376647 abstract "In 1981, Bowers reported that xenobiotic peptides, derived from the Leu- and Met- enkephalins, demonstrated novel growth hormone (GH) secretory activity [1,2]. The most potent peptide reported, GH releasing peptide-6 (GHRP-6), was shown to release GH by a different pathway to the known signalling peptide, growth hormone releasing hormone (GHRH). The discovery of a peptidyl GH secretagogue laid the foundation for the search for smaller, orally active mimetics of GHRP-6, as well as for its mechanism of action. This review focuses on the recent developments in the field of small molecule GH secretagogues from a medicinal chemistry perspective [3,4], and discusses various structural classes of mimetics recently reported in the literature." @default.
- W2000376647 created "2016-06-24" @default.
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- W2000376647 date "1997-12-01" @default.
- W2000376647 modified "2023-10-15" @default.
- W2000376647 title "Small molecule mimetics of GHRP-6" @default.
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- W2000376647 doi "https://doi.org/10.1517/13543784.6.12.1839" @default.
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