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- W2000377435 abstract "Significance CCCTC-binding factor (CTCF) is an epigenetic regulatory protein that is not only functionally diverse, but is also targeted to highly diverse DNA binding sites. CTCF cooperates with accessory proteins to achieve various functional outputs. Further evidence in Drosophila shows that CTCF may also be targeted to chromatin via accessory proteins. The identity of such mammalian proteins remains elusive. Herein, we describe evidence that the transcription factor general transcription factor II-I (TFII-I) targets CTCF binding to metabolism-related genes across the genome. We find that TFII-I regulates the transcription of genes within this network on the level of initiation via RNA polymerase II phosphorylation. These results provide a starting point for understanding a biological network communicating information between chromatin architecture, transcription, and metabolism." @default.
- W2000377435 created "2016-06-24" @default.
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- W2000377435 date "2015-02-02" @default.
- W2000377435 modified "2023-10-16" @default.
- W2000377435 title "Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I" @default.
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- W2000377435 doi "https://doi.org/10.1073/pnas.1416674112" @default.
- W2000377435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4343169" @default.
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