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- W2000378191 abstract "MANY physicians believe that goiter frequently develops during normal pregnancy.<sup>1,2</sup>In the course of gestation, increased urinary losses of iodide diminish the concentration of plasma inorganic iodide (PII) and produce a relative iodide deficiency.<sup>3</sup>Increased thyroidal clearance of iodide, frequently associated with thyroid gland enlargement, maintains normal absolute iodide uptake and thyroid hormone synthesis.<sup>3</sup> Dietary iodide deficiency may be another goitrogenic stimulus since goiters associated with pregnancy are more common in areas of reduced iodide intake.<sup>4</sup>Because dietary iodide intake has substantially increased in our geographic area,<sup>5</sup>we undertook the present study to reassess the prevalence of goiter and to determine the current concentration of PII during pregnancy. <h3>Subjects and Methods</h3> One of us (R.H.C.) examined 125 women within 24 hours of delivery. A brief history was taken and the size of the thyroid gland estimated by palpation. We consider a normal thyroid gland to" @default.
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- W2000378191 date "1979-07-27" @default.
- W2000378191 modified "2023-09-27" @default.
- W2000378191 title "Goiter and Plasma Inorganic Iodide Concentration in Pregnancy" @default.
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- W2000378191 doi "https://doi.org/10.1001/jama.1979.03300040038023" @default.
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