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- W2000378515 abstract "Fractional Exhaled Nitric Oxide (FENO) is reduced in asthmatic children by treatment with omalizumab, but not allergen immunotherapy. We studied the effect of allergen immunotherapy on FENO in adult subjects with allergic rhinitis and asthma. Seventeen subjects with both seasonal and perennial allergic rhinitis, age 34.9±12.1 (mean±SD) were treated with allergen immunotherapy and followed for one year with visits at baseline and 4, 8, 12, 24, and 52 weeks later. 11 were female, 9 had asthma, Body Mass Index (BMI) was 24.8±3.8. At baseline, 1subject was on inhaled steroids and 5 on nasal steroids. Allergic Rhinoconjunctivitis Symptoms (ARCS) and Asthma Control Test (ACT) scores at baseline were 6.4±4.2 and 22.7±4.4, respectively, FEV1 was 103.2±12.1%. Analyses were undertaken with STATA release 10 and significance accepted at alpha <0.05. FENO (measured in triplicate) was increased in our study subjects at baseline (36.2±23.4 ppb, 8-88), but did not significantly change throughout the follow-up period (p>0.39 between first and last study visit). No association was found between FENO and age, sex, BMI, number of positive skin tests, asthma (p>0.39), FEV1, or other spirometric values at any visit. However, a significant correlation was found between FENO and ARCS and ACT at the final visit (p<0.02). All but two study subjects judged the immunotherapy clinically effective at the end of the study. In adult subjects clinically effective allergen immunotherapy did not affect FENO. Validation of this finding should be undertaken in additional patient cohorts." @default.
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- W2000378515 date "2012-02-01" @default.
- W2000378515 modified "2023-10-05" @default.
- W2000378515 title "The Effect of Allergen Immunotherapy on Exhaled Nitric Oxide in Adult Subjects with Allergic Rhinitis and Asthma" @default.
- W2000378515 doi "https://doi.org/10.1016/j.jaci.2011.12.560" @default.
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