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- W2000379006 abstract "The intestinal lymphatic system is an alternate pathway to the portal blood by which orally administered drug molecules can gain access to the systemic circulation. The potential advantages of intestinal lymphatic transport include: (i) avoidance of first pass effect; (ii) delivery of selected drugs to the lymphatics; and (iii) controlled rate of entry to the systemic circulation. Highly lipophilic drugs and xenobiotics (logarithm of partition coefficient of at least 5–6 at physiological pH) transported by the intestinal lymphatics are associated with lipoproteins (primarily chylomicrons) formed by the enterocyte during lipid absorption and transport. This article describes the factors involved in the transport of highly lipophilic drugs by the intestinal lymphatics and discusses potential means for the promotion of intestinal lymphatic transport of lipophilic molecules." @default.
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- W2000379006 date "1991-07-01" @default.
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- W2000379006 title "Transport of lipophilic molecules by the intestinal lymphatic system" @default.
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- W2000379006 doi "https://doi.org/10.1016/0169-409x(91)90046-f" @default.
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