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• W2000379170 abstract "Background Clinical trials involving novel therapies treating acute heart failure syndromes (AHFS) have shown limited success with regard to both efficacy and safety. As a direct result, outcomes have changed little over time and AHFS remains a disease process associated with largely no change in hospitalization rates (80%), hospital length of stay (median 4.5 days), and in-hospital (4-7%) and 60-day mortality (10%). Despite extensive emergency department (ED) involvement during the initial phase of AHFS management, clinical trials have enrolled patients after the ED phase of management, up to 48 hours after initial therapy, long after many patients have experienced significant beneficial effects of standard therapy. As standard therapy has provided symptomatic improvement in up to 70% of patients in these trials, it is not surprising that investigational agents started after 24 to 48 hours of standard therapy have shown limited clinical efficacy when compared with standard therapy. Methods and Results The ability to screen, enroll, and randomize in the emergency setting is fundamental. The unique environment, the ethical complexities of enrollment in emergency-based research, and the need for rapid and standardized study-compliant care represent key challenges to active recruitment in AHFS studies. Specifically, the ability to identify and enroll a large cohort of AHFS patients early (<6 hours) in their presentation has been cited as the primary barrier to the appropriate design of clinical trials that includes this early window. Conclusions In response, we have created a network of dedicated academic physicians with experience in clinical trials and acute management of heart failure who together can surmount this barrier and provide a framework for conducting early trials in AHFS." @default.
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• W2000379170 date "2009-08-01" @default.
• W2000379170 modified "2023-09-27" @default.
• W2000379170 title "The Rationale for an Acute Heart Failure Syndromes Clinical Trials Network" @default.
• W2000379170 cites W124066534 @default.
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• W2000379170 cites W1572147214 @default.
• W2000379170 cites W1591880706 @default.
• W2000379170 cites W1966503041 @default.
• W2000379170 cites W1967255384 @default.
• W2000379170 cites W1970938282 @default.
• W2000379170 cites W1972068155 @default.
• W2000379170 cites W1975971363 @default.
• W2000379170 cites W1977759307 @default.
• W2000379170 cites W1978091522 @default.
• W2000379170 cites W1986096796 @default.
• W2000379170 cites W1988232724 @default.
• W2000379170 cites W1988816170 @default.
• W2000379170 cites W1991771263 @default.
• W2000379170 cites W1993823264 @default.
• W2000379170 cites W1997086580 @default.
• W2000379170 cites W1998220125 @default.
• W2000379170 cites W2004782018 @default.
• W2000379170 cites W2012751193 @default.
• W2000379170 cites W2018666773 @default.
• W2000379170 cites W2021624055 @default.
• W2000379170 cites W2027167742 @default.
• W2000379170 cites W2027382385 @default.
• W2000379170 cites W2034063870 @default.
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• W2000379170 cites W2052035791 @default.
• W2000379170 cites W2057061319 @default.
• W2000379170 cites W2058542276 @default.
• W2000379170 cites W2060042742 @default.
• W2000379170 cites W2070932763 @default.
• W2000379170 cites W2081617413 @default.
• W2000379170 cites W2097627126 @default.
• W2000379170 cites W2099691297 @default.
• W2000379170 cites W2107848854 @default.
• W2000379170 cites W2108780124 @default.
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• W2000379170 cites W2111514631 @default.
• W2000379170 cites W2112636786 @default.
• W2000379170 cites W2113313693 @default.
• W2000379170 cites W2114737064 @default.
• W2000379170 cites W2120934972 @default.
• W2000379170 cites W2121233204 @default.
• W2000379170 cites W2121902081 @default.
• W2000379170 cites W2122074886 @default.
• W2000379170 cites W2126896570 @default.
• W2000379170 cites W2127425580 @default.
• W2000379170 cites W2131468607 @default.
• W2000379170 cites W2132892126 @default.
• W2000379170 cites W2133893475 @default.
• W2000379170 cites W2140292987 @default.
• W2000379170 cites W2141703599 @default.
• W2000379170 cites W2142376738 @default.
• W2000379170 cites W2147588039 @default.
• W2000379170 cites W2160691650 @default.
• W2000379170 cites W2164846898 @default.
• W2000379170 cites W2168017932 @default.
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• W2000379170 cites W2292308933 @default.
• W2000379170 cites W2313196036 @default.
• W2000379170 cites W2313958625 @default.
• W2000379170 cites W2316599968 @default.
• W2000379170 cites W2328167306 @default.
• W2000379170 cites W4214856947 @default.
• W2000379170 cites W4238868571 @default.
• W2000379170 cites W4241169414 @default.
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• W2000379170 doi "https://doi.org/10.1016/j.cardfail.2008.12.013" @default.
• W2000379170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19643356" @default.
• W2000379170 hasPublicationYear "2009" @default.
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