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- W2000381178 abstract "Iodination of thyrotropin releasing factor (TRF) with chloramine-T and NaI at pH 7.5 produces both mono- and diiodo-TRF as well as unreacted TRF and I−. The four compounds can be separated by ion-exchange chromatography on SP-Sephadex C-25, using a stepwise gradient of 0.01 m MH4OAc at pH 3.5, 5.2 and 7.2. The monoiodo-TRF was characterized by nuclear magnetic resonance, mass spectra, and elemental analysis as [Im-5-iodo-His2]-TRF while the diiodo-TRF was similarly characterized as [Im-2,5-diiodo-His2]-TRF. Both iodination products showed no thyrotropin releasing activity at doses up to 1 μg in the in vivo mouse bioassay. The specific binding of mono- and diiodo-TRF was measured against three different TRF antisera. In the absence of TRF, antisera A and C bound more diiodo-TRF than monoiodo-TRF while antiserum B seemed to bind both tracers equally. In all cases steeper curves were produced when diiodo-TRF was displaced by synthetic TRF." @default.
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- W2000381178 date "1976-11-01" @default.
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- W2000381178 title "Chemical, biological, and immunological characterization of mono- and diiodo-thyrotropin releasing factor" @default.
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- W2000381178 doi "https://doi.org/10.1016/0003-2697(76)90270-0" @default.
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