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- W2000381214 abstract "Cell interactions with extracellular matrix, such as cell adhesion and spreading, are crucial for many biological functions and processes. Recent experimental progresses have demonstrated that substrate rigidities exert a remarkable influence on cell-substrate interfacial adhesion and spreading behaviors. The underlying biophysical mechanism, however, remains elusive. Based on the classical Bell-Dembo's theory, this paper develops a mechano-chemical coupling model to physically describe cell adhesion and spreading mediated by substrate stiffness. By investigating the competitive nature between cell-substrate specific attraction and non-specific repulsion, the kinetic relation of receptor-ligand interplay is established, in which the influences of receptor-ligand separation, substrate elasticity and non-specific repulsion on cell adhesions are especially addressed. According to mechanical equilibrium conditions between cell membranes and underlying elastic substrates, an analytical expression is then deduced to relate the cell-substrate interfacial adhesion strength to the substrate rigidity. Moreover, by means of the conventional wetting theory, the dependence of steady-state cell spreading on substrate stiffness is also quantitatively studied. Comparisons with the existing experimental data show that the proposed model can be used to explore cell-substrate interactions regulated by substrate rigidities." @default.
- W2000381214 created "2016-06-24" @default.
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- W2000381214 date "2011-03-01" @default.
- W2000381214 modified "2023-10-07" @default.
- W2000381214 title "Influence of substrate stiffness on cell–substrate interfacial adhesion and spreading: A mechano-chemical coupling model" @default.
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- W2000381214 doi "https://doi.org/10.1016/j.jcis.2010.12.055" @default.
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