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- W2000383988 abstract "1. A considerable number of modifications to the phenethylamine structure have provided useful pharmacological tools for studying regulation of food intake. The results of these studies show that anorectic drugs constitute a heterogeneous group, reducing food intake in animals by different mechanisms. 2. A review of evidence illustrates that pharmacologically induced changes in the activity of monoamine systems are associated with pronounced reduction in food intake. While catecholamines may be involved in the anorectic activity of stimulating agents such as amphetamine, the integrity of the serotoninergic system appears to be important for the reduction of food intake induced by the fenfluramine group. 3. The anorectic effect of mazindol seems to depend on both the noradrenergic and dopaminergic systems. However, biochemical information suggests an interaction between the central 5-HT and the nigroneostriatal DA pathways. 4. Structural modifications in the lateral chain need CF3 group for anorectic activity, while phenoxy substituted amphetamines have no effect on food intake, in spite of mild stimulant properties." @default.
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- W2000383988 date "1980-01-01" @default.
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- W2000383988 title "Substituted phenethylamines and anorexia" @default.
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- W2000383988 doi "https://doi.org/10.1016/0364-7722(80)90004-1" @default.
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