FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000384908> ?p ?o ?g. }

• W2000384908 endingPage "e1000446" @default.
• W2000384908 startingPage "e1000446" @default.
• W2000384908 abstract "Genomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory complexity of our genome. Here we combine a genome-wide approach to identify preferential sites of DNA replication initiation at 0.4% of the mouse genome with detailed molecular analysis at distinct classes of ORIs according to their location relative to the genes. Our study reveals that 85% of the replication initiation sites in mouse embryonic stem (ES) cells are associated with transcriptional units. Nearly half of the identified ORIs map at promoter regions and, interestingly, ORI density strongly correlates with promoter density, reflecting the coordinated organisation of replication and transcription in the mouse genome. Detailed analysis of ORI activity showed that CpG island promoter-ORIs are the most efficient ORIs in ES cells and both ORI specification and firing efficiency are maintained across cell types. Remarkably, the distribution of replication initiation sites at promoter-ORIs exactly parallels that of transcription start sites (TSS), suggesting a co-evolution of the regulatory regions driving replication and transcription. Moreover, we found that promoter-ORIs are significantly enriched in CAGE tags derived from early embryos relative to all promoters. This association implies that transcription initiation early in development sets the probability of ORI activation, unveiling a new hallmark in ORI efficiency regulation in mammalian cells." @default.
• W2000384908 created "2016-06-24" @default.
• W2000384908 creator A5013576902 @default.
• W2000384908 creator A5059262941 @default.
• W2000384908 creator A5064457047 @default.
• W2000384908 creator A5078274061 @default.
• W2000384908 creator A5079706088 @default.
• W2000384908 creator A5080620893 @default.
• W2000384908 date "2009-04-10" @default.
• W2000384908 modified "2023-10-17" @default.
• W2000384908 title "Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells" @default.
• W2000384908 cites W1577222190 @default.
• W2000384908 cites W1586384006 @default.
• W2000384908 cites W1603587119 @default.
• W2000384908 cites W1851269111 @default.
• W2000384908 cites W1968931043 @default.
• W2000384908 cites W1976058334 @default.
• W2000384908 cites W1979245454 @default.
• W2000384908 cites W1992220084 @default.
• W2000384908 cites W1999510229 @default.
• W2000384908 cites W2001199959 @default.
• W2000384908 cites W2007684630 @default.
• W2000384908 cites W2007844697 @default.
• W2000384908 cites W2015416439 @default.
• W2000384908 cites W2018590966 @default.
• W2000384908 cites W2037632104 @default.
• W2000384908 cites W2037686178 @default.
• W2000384908 cites W2040149948 @default.
• W2000384908 cites W2042350995 @default.
• W2000384908 cites W2057692691 @default.
• W2000384908 cites W2061481911 @default.
• W2000384908 cites W2062219202 @default.
• W2000384908 cites W2068394527 @default.
• W2000384908 cites W2071919914 @default.
• W2000384908 cites W2075432652 @default.
• W2000384908 cites W2088493129 @default.
• W2000384908 cites W2092235484 @default.
• W2000384908 cites W2096460454 @default.
• W2000384908 cites W2099117602 @default.
• W2000384908 cites W2101412414 @default.
• W2000384908 cites W2102223107 @default.
• W2000384908 cites W2102405388 @default.
• W2000384908 cites W2104190830 @default.
• W2000384908 cites W2109470020 @default.
• W2000384908 cites W2111206955 @default.
• W2000384908 cites W2113194068 @default.
• W2000384908 cites W2117166092 @default.
• W2000384908 cites W2122287535 @default.
• W2000384908 cites W2124564248 @default.
• W2000384908 cites W2124696903 @default.
• W2000384908 cites W2125734502 @default.
• W2000384908 cites W2127230663 @default.
• W2000384908 cites W2127779731 @default.
• W2000384908 cites W2128909466 @default.
• W2000384908 cites W2133752499 @default.
• W2000384908 cites W2133938268 @default.
• W2000384908 cites W2134071787 @default.
• W2000384908 cites W2143922456 @default.
• W2000384908 cites W2144141448 @default.
• W2000384908 cites W2145589035 @default.
• W2000384908 cites W2149114390 @default.
• W2000384908 cites W2149407399 @default.
• W2000384908 cites W2151464048 @default.
• W2000384908 cites W2153424791 @default.
• W2000384908 cites W2158610627 @default.
• W2000384908 cites W2159342107 @default.
• W2000384908 cites W2160449667 @default.
• W2000384908 cites W2161218950 @default.
• W2000384908 cites W2165372706 @default.
• W2000384908 cites W2170281020 @default.
• W2000384908 cites W4238656497 @default.
• W2000384908 doi "https://doi.org/10.1371/journal.pgen.1000446" @default.
• W2000384908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661365" @default.
• W2000384908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360092" @default.
• W2000384908 hasPublicationYear "2009" @default.
• W2000384908 type Work @default.
• W2000384908 sameAs 2000384908 @default.
• W2000384908 citedByCount "219" @default.
• W2000384908 countsByYear W20003849082012 @default.
• W2000384908 countsByYear W20003849082013 @default.
• W2000384908 countsByYear W20003849082014 @default.
• W2000384908 countsByYear W20003849082015 @default.
• W2000384908 countsByYear W20003849082016 @default.
• W2000384908 countsByYear W20003849082017 @default.
• W2000384908 countsByYear W20003849082018 @default.
• W2000384908 countsByYear W20003849082019 @default.
• W2000384908 countsByYear W20003849082020 @default.
• W2000384908 countsByYear W20003849082021 @default.
• W2000384908 countsByYear W20003849082022 @default.
• W2000384908 countsByYear W20003849082023 @default.
• W2000384908 crossrefType "journal-article" @default.
• W2000384908 hasAuthorship W2000384908A5013576902 @default.
• W2000384908 hasAuthorship W2000384908A5059262941 @default.
• W2000384908 hasAuthorship W2000384908A5064457047 @default.
• W2000384908 hasAuthorship W2000384908A5078274061 @default.
• W2000384908 hasAuthorship W2000384908A5079706088 @default.
• W2000384908 hasAuthorship W2000384908A5080620893 @default.
• W2000384908 hasBestOaLocation W20003849081 @default.

• next