FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000385771> ?p ?o ?g. }

• W2000385771 endingPage "151" @default.
• W2000385771 startingPage "146" @default.
• W2000385771 abstract "Cisplatin is an highly effective chemotherapeutic agent which produces a cumulative dose-limiting peripheral neuropathy. In this study, a possible role for microtubule abnormalities in cisplatin-induced toxicity was explored. CD rats (300 g) were injected daily ip with five doses of cisplatin (2 mg/kg) or every other day ip with two doses of cisplatin (10 mg/kg). The day after the last dose, the rats were killed and tubulin was purified from their testes. The maximal rate of cold-induced microtubule disassembly was consistently slower for testis tubulin purified from cisplatin-treated rats compared with control rats. Overnight in vitro coincubation of polymerized bovine brain tubulin with cisplatin followed by a purifying cycle of assembly and disassembly yielded tubulin capable of forming morphologically normal but short microtubules (average length: cisplatin-treated, 2.5 microns; control, 3.7 microns). Cisplatin coincubation markedly reduced the rate of cold-induced microtubule disassembly, producing a half-maximal effect at approximately 0.3 mM. The cold stability of cisplatin-treated microtubules could be partially reversed by diethyldithiocarbamate. Carboplatin, a cisplatin analog which does not cause clinical peripheral neuropathy, was less capable of producing microtubule disassembly abnormalities. These findings demonstrate the ability of cisplatin to alter microtubule disassembly by direct tubulin modification, an abnormality which may contribute to cisplatin-induced peripheral neuropathy." @default.
• W2000385771 created "2016-06-24" @default.
• W2000385771 creator A5036452445 @default.
• W2000385771 creator A5050625315 @default.
• W2000385771 creator A5053263729 @default.
• W2000385771 date "1992-09-01" @default.
• W2000385771 modified "2023-09-23" @default.
• W2000385771 title "cis-Diamminedichloroplatinum (II) (cisplatin) alters microtubule assembly dynamics" @default.
• W2000385771 cites W105069219 @default.
• W2000385771 cites W1543639545 @default.
• W2000385771 cites W1573559755 @default.
• W2000385771 cites W1723772693 @default.
• W2000385771 cites W1775749144 @default.
• W2000385771 cites W184164177 @default.
• W2000385771 cites W1964069971 @default.
• W2000385771 cites W1969779705 @default.
• W2000385771 cites W1971279835 @default.
• W2000385771 cites W1974002299 @default.
• W2000385771 cites W1977414956 @default.
• W2000385771 cites W1980244869 @default.
• W2000385771 cites W1980459836 @default.
• W2000385771 cites W1985499212 @default.
• W2000385771 cites W1986835506 @default.
• W2000385771 cites W1988482050 @default.
• W2000385771 cites W1989171626 @default.
• W2000385771 cites W1996953809 @default.
• W2000385771 cites W2001436364 @default.
• W2000385771 cites W2004366845 @default.
• W2000385771 cites W2007084342 @default.
• W2000385771 cites W2011075878 @default.
• W2000385771 cites W2015105750 @default.
• W2000385771 cites W2015653835 @default.
• W2000385771 cites W2037605675 @default.
• W2000385771 cites W2041997898 @default.
• W2000385771 cites W2051661023 @default.
• W2000385771 cites W2055154319 @default.
• W2000385771 cites W2064344222 @default.
• W2000385771 cites W2069191801 @default.
• W2000385771 cites W2081525624 @default.
• W2000385771 cites W2093129457 @default.
• W2000385771 cites W2103641926 @default.
• W2000385771 cites W2117226405 @default.
• W2000385771 cites W2123881536 @default.
• W2000385771 cites W2169211380 @default.
• W2000385771 cites W2227985333 @default.
• W2000385771 cites W2801553506 @default.
• W2000385771 cites W4239227502 @default.
• W2000385771 cites W67746198 @default.
• W2000385771 doi "https://doi.org/10.1016/0041-008x(92)90156-m" @default.
• W2000385771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1529448" @default.
• W2000385771 hasPublicationYear "1992" @default.
• W2000385771 type Work @default.
• W2000385771 sameAs 2000385771 @default.
• W2000385771 citedByCount "34" @default.
• W2000385771 countsByYear W20003857712012 @default.
• W2000385771 countsByYear W20003857712013 @default.
• W2000385771 countsByYear W20003857712014 @default.
• W2000385771 countsByYear W20003857712015 @default.
• W2000385771 countsByYear W20003857712016 @default.
• W2000385771 countsByYear W20003857712017 @default.
• W2000385771 countsByYear W20003857712018 @default.
• W2000385771 countsByYear W20003857712019 @default.
• W2000385771 countsByYear W20003857712020 @default.
• W2000385771 crossrefType "journal-article" @default.
• W2000385771 hasAuthorship W2000385771A5036452445 @default.
• W2000385771 hasAuthorship W2000385771A5050625315 @default.
• W2000385771 hasAuthorship W2000385771A5053263729 @default.
• W2000385771 hasConcept C126322002 @default.
• W2000385771 hasConcept C185592680 @default.
• W2000385771 hasConcept C20418707 @default.
• W2000385771 hasConcept C2776694085 @default.
• W2000385771 hasConcept C2778239845 @default.
• W2000385771 hasConcept C2781451048 @default.
• W2000385771 hasConcept C29730261 @default.
• W2000385771 hasConcept C71924100 @default.
• W2000385771 hasConcept C84425145 @default.
• W2000385771 hasConcept C86803240 @default.
• W2000385771 hasConcept C95444343 @default.
• W2000385771 hasConcept C98274493 @default.
• W2000385771 hasConceptScore W2000385771C126322002 @default.
• W2000385771 hasConceptScore W2000385771C185592680 @default.
• W2000385771 hasConceptScore W2000385771C20418707 @default.
• W2000385771 hasConceptScore W2000385771C2776694085 @default.
• W2000385771 hasConceptScore W2000385771C2778239845 @default.
• W2000385771 hasConceptScore W2000385771C2781451048 @default.
• W2000385771 hasConceptScore W2000385771C29730261 @default.
• W2000385771 hasConceptScore W2000385771C71924100 @default.
• W2000385771 hasConceptScore W2000385771C84425145 @default.
• W2000385771 hasConceptScore W2000385771C86803240 @default.
• W2000385771 hasConceptScore W2000385771C95444343 @default.
• W2000385771 hasConceptScore W2000385771C98274493 @default.
• W2000385771 hasIssue "1" @default.
• W2000385771 hasLocation W20003857711 @default.
• W2000385771 hasLocation W20003857712 @default.
• W2000385771 hasOpenAccess W2000385771 @default.
• W2000385771 hasPrimaryLocation W20003857711 @default.
• W2000385771 hasRelatedWork W2000385771 @default.
• W2000385771 hasRelatedWork W2023777392 @default.

• next