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• W2000388690 abstract "Abstract Background Several genes are associated with an increased susceptibility to asthma, which may be exacerbated by ambient air pollution. These genes include GSTM1 (glutathione‐ S ‐transferase M1 gene) and GSTP1 (glutathione‐ S ‐transferase P1 gene), which may modulate the response to epithelial oxidative changes caused by air pollutant exposure. This study evaluated fluctuations in the forced expiratory volume in one second (FEV 1 ) in relation to lagged daily averages of ambient air pollutants (SO 2 , NO 2 , NO, and PM 10 ) while considering genotype as an effect modifier. Methods A longitudinal cohort of 129 schoolchildren of African descent from Durban, South Africa was assessed. GSTM1 (null vs. present genotype) and GSTP1 (Ile105Val; AA → AG/GG) genotypes were determined using standard techniques. SO 2 , NO 2 , NO, and PM 10 were measured continuously over a year using validated methods. The outcome was intraday variability in FEV 1 . Data were collected daily over a 3‐week period in each of four seasons (2004–2005). Results Among the children tested, 27% had the GSTM1 null genotype and 81% carried the GSTP1 G allele. Approximately 26 out 104 children (25%) showed evidence of bronchial hyperreactivity, 13% reported having symptoms in keeping with persistent asthma, and a further 25% reported symptoms of mild intermittent asthma. PM 10 and SO 2 levels were moderately high relative to international guidelines. Neither GSTM1 nor GSTP1 genotypes alone were significantly associated with FEV 1 intraday variability. In models not including genotype, FEV 1 variability was statistically significantly associated only with NO 2 for 5‐day lags (% change in intraday variability in FEV1 per interquartile range = 1.59, CI 0.58, 2.61). The GSTP1 genotype modified the effect of 3 days prior 24‐hr average PM 10 and increased FEV 1 variability. A similar pattern was observed for lagged 3 day SO 2 exposure ( P interaction < 0.05). Adverse effects of these pollutants were limited to individuals carrying the G allele for this polymorphism. Conclusion Among this indigenous South African children cohort, the GSTP1 genotype modified the effects of ambient exposures to PM 10 and SO 2 and lung function. A plausible mechanism for these observed effects is decreased capacity to mount an effective response to oxidative stress associated with the GSTP1 AG + GG genotype. Am. J. Ind. Med. 55:1078–1086, 2012. © 2012 Wiley Periodicals, Inc." @default.
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• W2000388690 date "2012-01-06" @default.
• W2000388690 modified "2023-10-09" @default.
• W2000388690 title "<i>GSTM1</i>and<i>GSTP1</i>gene variants and the effect of air pollutants on lung function measures in South African children" @default.
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• W2000388690 doi "https://doi.org/10.1002/ajim.22012" @default.
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