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- W2000388911 abstract "Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy." @default.
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- W2000388911 date "1995-02-01" @default.
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- W2000388911 title "Synovial tissue response to treatment with campath-1h" @default.
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- W2000388911 doi "https://doi.org/10.1002/art.1780380215" @default.
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