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• W2000389367 abstract "This article reviews studies that have measured drug concentrations in oral fluid following controlled dosing regimens. A total of 23 studies have been identified over the last 15 years. These show that the amphetamines including designer amphetamines, cocaine, cannabis and cocaine are quickly found in oral fluid following dosing and usually have similar time-courses to that in plasma. Following common doses peak oral fluid concentrations exceed 0.1 μg/mL and often even 1 μg/mL. The drug concentration will depend on whether a dilution step occurs with buffer as part of the sampling procedure. The uses of collectors that stimulate oral fluid usually reduce the drug concentration compared to a non-stimulated manner. This reduction will not disadvantage the recipient since it will potentially reduce the detectablity of drug in oral fluid compared to non-stimulated collections. Only one recent study has been reported for a benzodiazepine. This showed nanogram per milliliter concentrations for flunitrazepam. More studies are required for benzodiazepines and indeed for other drugs, particularly in multiple drug situations and where disease may affect the pharmacokinetics of drugs." @default.
• W2000389367 created "2016-06-24" @default.
• W2000389367 creator A5053953317 @default.
• W2000389367 date "2005-06-01" @default.
• W2000389367 modified "2023-10-10" @default.
• W2000389367 title "Review: Pharmacokinetics of illicit drugs in oral fluid" @default.
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• W2000389367 doi "https://doi.org/10.1016/j.forsciint.2004.11.022" @default.
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