FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000389519> ?p ?o ?g. }

• W2000389519 endingPage "34" @default.
• W2000389519 startingPage "24" @default.
• W2000389519 abstract "A series of synthetic analogs of naturally occurring glycerophospholipids has been studied for gel-to-liquid transition temperature (Tc) by using differential scanning calorimetry. The compounds investigated were dihexadecyl phosphatidylcholine (DHPC) plus 11 newly synthesized phosphonolipids. Six were racemates and have ether-ether fatty chains and 5 were chiral (R) with ether-amide fatty chains bonded to the glycerol moiety; each series also contained a methylene isosteric substitution for one of the oxygen atoms in naturally occurring glycerophospholipid phosphate esters. All analogs have fatty chains of equivalent length in saturated carbon atoms C2C16, but varied in N-headgroup structures. The thermal behaviors of these novel molecules were found to depend upon the degree of alkylation of the headgroups and upon whether the hydrocarbon chains are bonded as ethers or amides. The ether-ether (diether) phosphonolipid (DEPN) analogs of dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidylethanolamine (DPPE) had increased gel-to-liquid crystal transition temperatures (Tc) compared to their naturally occurring (fatty acyl ester) glycerophospholipid counterparts. In general, DEPN analogs had Tc values 3.7−5.8°C higher than ether-amide phosophonolipid (EAPN) compounds of equivalent headgroup, although EAPN-13 was an exception with the highest Tc of any compound studied. In both the DEPN and EAPN series, analogs with hydrogen atom(s) covalently bonded to the headgroup nitrogen atom showed higher Tc values, possibly related to their increased potential for hydrogen bonding. Interfacial property studies (adsorption, Wilhelmy balance, oscillating bubble) showed that several analogs with higher transitions than DPPC, the principal lung surfactant glycerophospholipid, had improved adsorption and respreading, with equivalent surface tension lowering in compressed spread films on the balance and with minimum surface tensions <1 mN/m in pulsated dispersions on the bubble. Surface activity did not correlate simply with Tc and results suggested that other factors, such as molecular shape (wedge shaped as in phosphatidylethanolamine, PE) or bilayer structure (interdigitated as in DHPC) may be important in understanding dynamic respreading differences in interfacial films compressed dynamically past collapse." @default.
• W2000389519 created "2016-06-24" @default.
• W2000389519 creator A5015316695 @default.
• W2000389519 creator A5020672465 @default.
• W2000389519 creator A5039827169 @default.
• W2000389519 creator A5071826171 @default.
• W2000389519 creator A5085037354 @default.
• W2000389519 date "1992-11-01" @default.
• W2000389519 modified "2023-10-14" @default.
• W2000389519 title "Differential scanning calorimetry studies of phosphonolipid analogs of lung surfactant glycerophospholipids" @default.
• W2000389519 cites W1917099971 @default.
• W2000389519 cites W1966703304 @default.
• W2000389519 cites W1978468660 @default.
• W2000389519 cites W1989808058 @default.
• W2000389519 cites W1990550159 @default.
• W2000389519 cites W1996380871 @default.
• W2000389519 cites W1998860125 @default.
• W2000389519 cites W1999518959 @default.
• W2000389519 cites W2007631852 @default.
• W2000389519 cites W2009475191 @default.
• W2000389519 cites W2011359879 @default.
• W2000389519 cites W2012448047 @default.
• W2000389519 cites W2014033613 @default.
• W2000389519 cites W2017069757 @default.
• W2000389519 cites W2019130726 @default.
• W2000389519 cites W2020637502 @default.
• W2000389519 cites W2022631293 @default.
• W2000389519 cites W2024156929 @default.
• W2000389519 cites W2029666271 @default.
• W2000389519 cites W2029746709 @default.
• W2000389519 cites W2029811873 @default.
• W2000389519 cites W2031180458 @default.
• W2000389519 cites W2032083637 @default.
• W2000389519 cites W2033393971 @default.
• W2000389519 cites W2046025180 @default.
• W2000389519 cites W2052603172 @default.
• W2000389519 cites W2054881884 @default.
• W2000389519 cites W2061485665 @default.
• W2000389519 cites W2061595163 @default.
• W2000389519 cites W2069885244 @default.
• W2000389519 cites W2074483025 @default.
• W2000389519 cites W2085938353 @default.
• W2000389519 cites W2104491508 @default.
• W2000389519 cites W2116628043 @default.
• W2000389519 cites W2186869550 @default.
• W2000389519 cites W2261863169 @default.
• W2000389519 cites W93563661 @default.
• W2000389519 doi "https://doi.org/10.1016/0021-9797(92)90075-w" @default.
• W2000389519 hasPublicationYear "1992" @default.
• W2000389519 type Work @default.
• W2000389519 sameAs 2000389519 @default.
• W2000389519 citedByCount "6" @default.
• W2000389519 countsByYear W20003895192012 @default.
• W2000389519 countsByYear W20003895192013 @default.
• W2000389519 crossrefType "journal-article" @default.
• W2000389519 hasAuthorship W2000389519A5015316695 @default.
• W2000389519 hasAuthorship W2000389519A5020672465 @default.
• W2000389519 hasAuthorship W2000389519A5039827169 @default.
• W2000389519 hasAuthorship W2000389519A5071826171 @default.
• W2000389519 hasAuthorship W2000389519A5085037354 @default.
• W2000389519 hasBestOaLocation W20003895191 @default.
• W2000389519 hasConcept C112887158 @default.
• W2000389519 hasConcept C121332964 @default.
• W2000389519 hasConcept C178790620 @default.
• W2000389519 hasConcept C185592680 @default.
• W2000389519 hasConcept C2776330855 @default.
• W2000389519 hasConcept C2776952329 @default.
• W2000389519 hasConcept C2777454769 @default.
• W2000389519 hasConcept C2778439535 @default.
• W2000389519 hasConcept C2778918659 @default.
• W2000389519 hasConcept C2780407432 @default.
• W2000389519 hasConcept C2909522894 @default.
• W2000389519 hasConcept C32909587 @default.
• W2000389519 hasConcept C39519442 @default.
• W2000389519 hasConcept C41625074 @default.
• W2000389519 hasConcept C55493867 @default.
• W2000389519 hasConcept C71240020 @default.
• W2000389519 hasConcept C8010536 @default.
• W2000389519 hasConcept C97355855 @default.
• W2000389519 hasConceptScore W2000389519C112887158 @default.
• W2000389519 hasConceptScore W2000389519C121332964 @default.
• W2000389519 hasConceptScore W2000389519C178790620 @default.
• W2000389519 hasConceptScore W2000389519C185592680 @default.
• W2000389519 hasConceptScore W2000389519C2776330855 @default.
• W2000389519 hasConceptScore W2000389519C2776952329 @default.
• W2000389519 hasConceptScore W2000389519C2777454769 @default.
• W2000389519 hasConceptScore W2000389519C2778439535 @default.
• W2000389519 hasConceptScore W2000389519C2778918659 @default.
• W2000389519 hasConceptScore W2000389519C2780407432 @default.
• W2000389519 hasConceptScore W2000389519C2909522894 @default.
• W2000389519 hasConceptScore W2000389519C32909587 @default.
• W2000389519 hasConceptScore W2000389519C39519442 @default.
• W2000389519 hasConceptScore W2000389519C41625074 @default.
• W2000389519 hasConceptScore W2000389519C55493867 @default.
• W2000389519 hasConceptScore W2000389519C71240020 @default.
• W2000389519 hasConceptScore W2000389519C8010536 @default.
• W2000389519 hasConceptScore W2000389519C97355855 @default.
• W2000389519 hasIssue "1" @default.

• next