FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000389735> ?p ?o ?g. }

• W2000389735 endingPage "2214" @default.
• W2000389735 startingPage "2207" @default.
• W2000389735 abstract "Studies in vitro suggested that inflammatory cytokines could cause myocardial dysfunction. However, the detailed mechanism for the cytokine-induced myocardial dysfunction in vivo remains to be examined. We thus examined this point in our new canine model in vivo, in which microspheres with and without IL-1beta were injected into the left main coronary artery. Left ventricular ejection fraction (LVEF) was evaluated by echocardiography for 1 wk. Immediately after the microsphere injection, LVEF decreased to approximately 30% in both groups. While LVEF rapidly normalized in 2 d in the control group, it was markedly impaired in the IL-1beta group even at day 7. Pretreatment with dexamethasone or with aminoguanidine, an inhibitor of inducible nitric oxide synthase, prevented the IL-1beta-induced myocardial dysfunction. Nitrotyrosine concentration, an in vivo marker of the peroxynitrite production by nitric oxide and superoxide anion, was significantly higher in the myocardium of the IL-1beta group than in that of the control group or the group cotreated with dexamethasone or aminoguanidine. There was an inverse linear relationship between myocardial nitrotyrosine concentrations and LVEF. These results indicate that IL-1beta induces sustained myocardial dysfunction in vivo and that nitric oxide produced by inducible nitric oxide synthase and the resultant formation of peroxynitrite are substantially involved in the pathogenesis of the cytokine-induced sustained myocardial dysfunction in vivo." @default.
• W2000389735 created "2016-06-24" @default.
• W2000389735 creator A5012657143 @default.
• W2000389735 creator A5023977297 @default.
• W2000389735 creator A5032092158 @default.
• W2000389735 creator A5052770369 @default.
• W2000389735 creator A5065276833 @default.
• W2000389735 creator A5065901351 @default.
• W2000389735 creator A5067505160 @default.
• W2000389735 creator A5067786455 @default.
• W2000389735 creator A5075158215 @default.
• W2000389735 date "1998-05-15" @default.
• W2000389735 modified "2023-10-16" @default.
• W2000389735 title "Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo." @default.
• W2000389735 cites W1496717884 @default.
• W2000389735 cites W1505685265 @default.
• W2000389735 cites W1747994692 @default.
• W2000389735 cites W1822099413 @default.
• W2000389735 cites W1832460954 @default.
• W2000389735 cites W1845689355 @default.
• W2000389735 cites W1889558125 @default.
• W2000389735 cites W1982947678 @default.
• W2000389735 cites W1985812804 @default.
• W2000389735 cites W1991330169 @default.
• W2000389735 cites W1995138632 @default.
• W2000389735 cites W1996888086 @default.
• W2000389735 cites W2003671526 @default.
• W2000389735 cites W2012514914 @default.
• W2000389735 cites W2015172293 @default.
• W2000389735 cites W2015639803 @default.
• W2000389735 cites W2019951936 @default.
• W2000389735 cites W2020358486 @default.
• W2000389735 cites W2025372788 @default.
• W2000389735 cites W2045846314 @default.
• W2000389735 cites W2047779506 @default.
• W2000389735 cites W2054345018 @default.
• W2000389735 cites W2056761641 @default.
• W2000389735 cites W2058137293 @default.
• W2000389735 cites W2068294014 @default.
• W2000389735 cites W2073546342 @default.
• W2000389735 cites W2078587014 @default.
• W2000389735 cites W2093453769 @default.
• W2000389735 cites W2094745968 @default.
• W2000389735 cites W2100931753 @default.
• W2000389735 cites W2107212779 @default.
• W2000389735 cites W2109893157 @default.
• W2000389735 cites W2110023021 @default.
• W2000389735 cites W2113130764 @default.
• W2000389735 cites W2115929723 @default.
• W2000389735 cites W2120768528 @default.
• W2000389735 cites W2121459138 @default.
• W2000389735 cites W2137570167 @default.
• W2000389735 cites W2147750240 @default.
• W2000389735 cites W2152606137 @default.
• W2000389735 cites W2166542918 @default.
• W2000389735 cites W2188202999 @default.
• W2000389735 cites W2253705614 @default.
• W2000389735 cites W2265277925 @default.
• W2000389735 cites W2284280435 @default.
• W2000389735 cites W2324476825 @default.
• W2000389735 cites W2413503736 @default.
• W2000389735 cites W4211053163 @default.
• W2000389735 doi "https://doi.org/10.1172/jci986" @default.
• W2000389735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508808" @default.
• W2000389735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9593776" @default.
• W2000389735 hasPublicationYear "1998" @default.
• W2000389735 type Work @default.
• W2000389735 sameAs 2000389735 @default.
• W2000389735 citedByCount "108" @default.
• W2000389735 countsByYear W20003897352012 @default.
• W2000389735 countsByYear W20003897352013 @default.
• W2000389735 countsByYear W20003897352014 @default.
• W2000389735 countsByYear W20003897352015 @default.
• W2000389735 countsByYear W20003897352017 @default.
• W2000389735 countsByYear W20003897352018 @default.
• W2000389735 countsByYear W20003897352021 @default.
• W2000389735 countsByYear W20003897352022 @default.
• W2000389735 crossrefType "journal-article" @default.
• W2000389735 hasAuthorship W2000389735A5012657143 @default.
• W2000389735 hasAuthorship W2000389735A5023977297 @default.
• W2000389735 hasAuthorship W2000389735A5032092158 @default.
• W2000389735 hasAuthorship W2000389735A5052770369 @default.
• W2000389735 hasAuthorship W2000389735A5065276833 @default.
• W2000389735 hasAuthorship W2000389735A5065901351 @default.
• W2000389735 hasAuthorship W2000389735A5067505160 @default.
• W2000389735 hasAuthorship W2000389735A5067786455 @default.
• W2000389735 hasAuthorship W2000389735A5075158215 @default.
• W2000389735 hasBestOaLocation W20003897351 @default.
• W2000389735 hasConcept C126322002 @default.
• W2000389735 hasConcept C134018914 @default.
• W2000389735 hasConcept C150903083 @default.
• W2000389735 hasConcept C181199279 @default.
• W2000389735 hasConcept C185592680 @default.
• W2000389735 hasConcept C207001950 @default.
• W2000389735 hasConcept C2777622882 @default.
• W2000389735 hasConcept C2778198053 @default.
• W2000389735 hasConcept C2778690821 @default.
• W2000389735 hasConcept C2778784160 @default.

• next