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• W2000392885 abstract "Stathmin is a ubiquitous cytosolic regulatory phosphoprotein and is overexpressed in different human malignancies. The main physiological function of stathmin is to interfere with microtubule dynamics by promoting depolymerization of microtubules or by preventing polymerization of tubulin heterodimers. Stathmin plays important roles in regulating many cellular functions as a result of its microtubule-destabilizing activity. Currently, the critical roles of stathmin in cancer cells, as well as in lymphocytes have been valued. This review discusses stathmin and microtubule dynamics in cancer development, and hypothesizes their possible relationship with epithelial-mesenchymal transition (EMT).A PubMed search using such terms as stathmin, microtubule dynamics, epithelial-mesenchymal transition, EMT, malignant potential and cancer was performed to identify relevant studies published in English. More than 100 related articles were reviewed.The literature clearly documented the relationship between stathmin and its microtubule-destabilizing activity of cancer development. However, the particular mechanism is poorly understood. Microtubule disruption is essential for EMT, which is a crucial process during cancer development. As a microtubule-destabilizing protein, stathmin may promote malignant potential in cancer cells by initiating EMT.We propose that there is a stathmin-microtubule dynamics-EMT (S-M-E) axis during cancer development. By this axis, stathmin together with its microtubule-destabilizing activity contributes to EMT, which stimulates the malignant potential in cancer cells." @default.
• W2000392885 created "2016-06-24" @default.
• W2000392885 creator A5003235062 @default.
• W2000392885 creator A5003360183 @default.
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• W2000392885 creator A5027427175 @default.
• W2000392885 creator A5035064408 @default.
• W2000392885 creator A5078370650 @default.
• W2000392885 date "2014-08-01" @default.
• W2000392885 modified "2023-10-16" @default.
• W2000392885 title "Stathmin destabilizing microtubule dynamics promotes malignant potential in cancer cells by epithelial-mesenchymal transition" @default.
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