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- W2000393349 abstract "We have previously shown that the increase in the slope of alveolar plateau for nitrogen (SN2) obtained during a single-breath washout test performed in seated posture detects bronchiolitis obliterans before standard pulmonary function in recipients of bilateral lung transplantation (AJRCCM 2000;162:1047); this technique, however, is not applicable to recipients of SLT because of the confounding influence of the native lung. In the present study, we tested the hypothesis that measuring SN2 in the right and left lateral decubitus may allow to distinguish between the graft and the native lung. Because the dependent and independent lungs empty according to a gravity-based sequence with the independent lung contributing preferentially at the end of expiration, we hypothesized that SN2 would differ according to the position of the graft. We studied 12 SLT patients (7 F and 5 M, age 55±9 yrs) who had been transplanted for emphysema (n=9) or IPF (n=3) 1194 days (range 48–4393) earlier and were in stable clinical condition; SN2 over the last 25% of the expiratory volume was measured with the patient in the right and left lateral decubitus. In all patients, SN2 was much greater with the native lung in the independent position than with the graft in the independent position, reflecting the predominant contribution of the independent lung to the late part of expiration; in 5 patients SN2 was even negative when the graft was in the independent position. Expressed in % of mean N2 concentration per % of expired volume, SN2 averaged 0.764±0.343 (native independent) and 0.058±0.326 (graft independent) (p<0.001). We conclude that measuring SN2 in lateral decubitus allows to distinguish between the graft and the native lung; this technique may therefore be useful to monitor the ofunction of the graft after SLT and detect the development of bronchiolitis obliterans." @default.
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- W2000393349 date "2005-02-01" @default.
- W2000393349 modified "2023-09-23" @default.
- W2000393349 title "Assessment of graft function after Single-Lung Transplantation (SLT) by single-breath washout in lateral decubitus" @default.
- W2000393349 doi "https://doi.org/10.1016/j.healun.2004.11.081" @default.
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