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• W2000393436 abstract "There is no clear concept concerning the role of immune disorders in pathogenesis of metabolic syndrome (MS). The aim of the study was to evaluate the levels of antiphospholipid antibodies dependently of arterial hypertension (AH) stages and hypertension's complications appearance in patients with verified MS. 55 patients with MS were involved into the study (30 men and 25 women, mean 48.4±4.1 years old): the 1st group included 25 patients with MS and moderate AH; the 2nd group – 20 patients with severe AH (stage 3), complicated with cerebral ischemic insults and acute myocardial infarctions; control group included 10 patients with mild AH stage 1 (without target organs injury). For research purpose the antibodies to cardiolipine (AKL) isotypes IgG and IgM were typified with the standard immune-enzyme method (ELISA), titres of antibodies to myocardial, renal, cerebral and vascular intimae antigens were investigated. In patients of the 1st group average systolic blood pressure (SBP) was 180.0±10.3 Hg mm., diastolic blood pressure (DBP) was 105.0±8.7 Hg mm., in the 2nd group – SBP was 205±21,8 Hg mm., DBP – 110,5±10,1 Hg mm. Isotype of IgMG-AKL antibodies' increasing was in 5 patients of the 1st group. Isotypes of IgG-AKL and IgM-AKL antibodies increased in 5 and 4 patients of the 2nd group, accordingly. The titres of antibodies to myocardial, renal, cerebral and vasculars intima antigents were significantly higher in the patients of the 1st and 2nd groups comparatively to the control group (p<0.05). Level of antibodies to target-organs antigens most closely correlated to the diastolic blood pressure in the 2nd group (the highest correlation indices to the all research target-organs). Smaller but still strong correlation coefficients of DBP to target-organs antigens antibodies were in 1st group. The power of correlative relations between antiphospholipid antibodies levels to target-organs antigens depends on arterial blood pressure level and AH's complications appearance in patients with MS. Antiphospholipid antibodies were found in 31% patients with MS. Either level of IgG-AKL and IgM-AKL or antiintimae, antirenal, antimyocardial and anticerebral antibodies was respective to AH stage showing dependences between target organs failure and immune disorders. Am J Hypertens (2004) 17, 219A–219A; doi: 10.1016/j.amjhyper.2004.03.583" @default.
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• W2000393436 date "2004-05-01" @default.
• W2000393436 modified "2023-09-23" @default.
• W2000393436 title "Antiphospholipid syndrome and metabolic syndrome - myth or pathogenetic reality?" @default.
• W2000393436 doi "https://doi.org/10.1016/j.amjhyper.2004.03.583" @default.
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