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• W2000394052 startingPage "1393" @default.
• W2000394052 abstract "Ancient Y-chromosomes of various organisms contain few active genes and an abundance of repetitive DNA. The neo-Y chromosome of Drosophila miranda is in transition from an ordinary autosome to a genetically inert Y-chromosome, while its homolog, the neo-X chromosome, is evolving partial dosage compensation. Here, I compare four large genomic regions located on the neo-sex chromosomes that contain a total of 12 homologous genes. In addition, I investigate the partial coding sequence for 56 more homologous gene pairs from the neo-sex chromosomes. Little modification has occurred on the neo-X chromosome, and genes are highly constrained at the protein level. In contrast, a diverse array of molecular changes is contributing to the observed degeneration of the neo-Y chromosome. In particular, the four large regions surveyed on the neo-Y chromosome harbor several transposable element insertions, large deletions, and a large structural rearrangement. About one-third of all neo-Y-linked genes are nonfunctional, containing either premature stop codons and/or frameshift mutations. Intact genes on the neo-Y are accumulating amino acid and unpreferred codon changes. In addition, both 5′- and 3′-flanking regions of genes and intron sequences are less constrained on the neo-Y relative to the neo-X. Despite heterogeneity in levels of dosage compensation along the neo-X chromosome of D. miranda , the neo-Y chromosome shows surprisingly uniform signs of degeneration." @default.
• W2000394052 created "2016-06-24" @default.
• W2000394052 creator A5000932897 @default.
• W2000394052 date "2005-09-16" @default.
• W2000394052 modified "2023-10-01" @default.
• W2000394052 title "Sex chromosome evolution: Molecular aspects of Y-chromosome degeneration in <i>Drosophila</i>" @default.
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• W2000394052 doi "https://doi.org/10.1101/gr.3543605" @default.
• W2000394052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1240082" @default.
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• W2000394052 hasPublicationYear "2005" @default.
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