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- W2000394086 abstract "The formation of nonfibrillar oligomers has been proposed as a common element of the aggregation pathway of proteins and peptides associated with neurodegenerative diseases such as Alzheimer’s and Creutzfeldt−Jakob disease. While fibrillar structures have long been considered indicators of diseases linked with the accumulation of amyloid plaques, it has more recently been proposed that amyloid oligomers are in fact the cytotoxic form. Here we describe the local structure and dynamics of stable oligomers formed by a peptide comprising residues 106−126 of the human prion protein (PrP). Structural constraints from solid-state NMR reveal quaternary packing interactions within the hydrophobic core, similar to those previously reported for amyloid fibrils formed by this peptide, and consistent with structural studies of oligomers formed by the Alzheimer’s β-amyloid peptide. However, a hydration-dependent increase in disorder is observed for nonfibrillar oligomers of PrP(106−126). In solution NMR spectra we observe narrow 1H and 13C resonances corresponding to a monomer in exchange with the ∼30 nm diameter nonfibrillar oligomers, giving additional information on the molecular structure of these species. Taken together, our data support a model in which the local structure of the oligomers contains the basic elements of amyloid fibrils, but with long-range disorder and local mobility that distinguishes these assemblies from the fibrillar form of PrP(106−126). These characteristics may provide a basis for the differing biological activities of amyloid fibrils and oligomers." @default.
- W2000394086 created "2016-06-24" @default.
- W2000394086 creator A5022841391 @default.
- W2000394086 creator A5055121704 @default.
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- W2000394086 date "2010-05-13" @default.
- W2000394086 modified "2023-09-27" @default.
- W2000394086 title "Structural Properties and Dynamic Behavior of Nonfibrillar Oligomers Formed by PrP(106−126)" @default.
- W2000394086 cites W1589295940 @default.
- W2000394086 cites W1945903641 @default.
- W2000394086 cites W1964727310 @default.
- W2000394086 cites W1966910457 @default.
- W2000394086 cites W1967460064 @default.
- W2000394086 cites W1972409470 @default.
- W2000394086 cites W1972459558 @default.
- W2000394086 cites W1972882343 @default.
- W2000394086 cites W1980825524 @default.
- W2000394086 cites W1981596913 @default.
- W2000394086 cites W1982684050 @default.
- W2000394086 cites W1989269014 @default.
- W2000394086 cites W1991919068 @default.
- W2000394086 cites W1995075732 @default.
- W2000394086 cites W1996037698 @default.
- W2000394086 cites W2002869713 @default.
- W2000394086 cites W2003589347 @default.
- W2000394086 cites W2006731694 @default.
- W2000394086 cites W2007242005 @default.
- W2000394086 cites W2008386999 @default.
- W2000394086 cites W2009556855 @default.
- W2000394086 cites W2011847302 @default.
- W2000394086 cites W2026306293 @default.
- W2000394086 cites W2026380581 @default.
- W2000394086 cites W2027105865 @default.
- W2000394086 cites W2028476667 @default.
- W2000394086 cites W2029422688 @default.
- W2000394086 cites W2032392220 @default.
- W2000394086 cites W2034121963 @default.
- W2000394086 cites W2043642345 @default.
- W2000394086 cites W2050146983 @default.
- W2000394086 cites W2052517492 @default.
- W2000394086 cites W2053402937 @default.
- W2000394086 cites W2056776699 @default.
- W2000394086 cites W2058368188 @default.
- W2000394086 cites W2067214887 @default.
- W2000394086 cites W2068227670 @default.
- W2000394086 cites W2068810698 @default.
- W2000394086 cites W2069076176 @default.
- W2000394086 cites W2069734146 @default.
- W2000394086 cites W2072613948 @default.
- W2000394086 cites W2073699804 @default.
- W2000394086 cites W2074770586 @default.
- W2000394086 cites W2076283593 @default.
- W2000394086 cites W2082176639 @default.
- W2000394086 cites W2084280842 @default.
- W2000394086 cites W2084761689 @default.
- W2000394086 cites W2084963421 @default.
- W2000394086 cites W2086565576 @default.
- W2000394086 cites W2089618587 @default.
- W2000394086 cites W2093861673 @default.
- W2000394086 cites W2094525223 @default.
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- W2000394086 cites W2122582863 @default.
- W2000394086 cites W2132521116 @default.
- W2000394086 cites W2136219546 @default.
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- W2000394086 cites W2146704107 @default.
- W2000394086 cites W2149478284 @default.
- W2000394086 cites W2150999725 @default.
- W2000394086 cites W2152419135 @default.
- W2000394086 cites W2165021720 @default.
- W2000394086 cites W2169101094 @default.
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- W2000394086 doi "https://doi.org/10.1021/ja100431q" @default.
- W2000394086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20465257" @default.
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