Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000394421> ?p ?o ?g. }
- W2000394421 endingPage "1070" @default.
- W2000394421 startingPage "1062" @default.
- W2000394421 abstract "The signaling pathways of TC21-mediated transformation and cell survival are not well-established. In this study, we have investigated the role of PI3-K/Akt signaling pathway in oncogenic-TC21-mediated transformation and cell survival. We found that oncogenic-TC21 stimulated the PI3-K activity. This was associated with the activation of Akt, a key component of PI3-K signaling pathway. We also found that TC21 interacted and formed complex with PI3-K. Mutations in the GTP-binding region of TC21, which enhanced GTP-binding potential of this protein, also stimulated its association with PI3-K, suggesting that PI3-K may preferentially interact with the GTP-bound form. Suppression of PI3-K and Akt by specific inhibitors LY294002 and Wortmannin reversed TC21-induced transformation. Likewise, inhibition of PI3-K activity by the PI3-K phosphotase PTEN reduced TC21-mediated focus formation in NIH3T3 cells. Investigation of TC21's effect on cell survival revealed that mutant-TC21 expressing cells were more resistant to etoposide- and cisplatin-induced cell death, and this was associated with the activation of anti-apoptotic protein NF-κB, a downstream target of Akt. Treatment of PI3-K inhibitor LY294002 significantly suppressed TC21-mediated NF-κB activation. In conclusion, we have identified PI3-K as an effector of TC21 and demonstrated that the PI3-K/Akt signaling pathway plays important roles in TC21-mediated transformation and cell survival." @default.
- W2000394421 created "2016-06-24" @default.
- W2000394421 creator A5010579783 @default.
- W2000394421 creator A5020115662 @default.
- W2000394421 creator A5042708757 @default.
- W2000394421 creator A5081065929 @default.
- W2000394421 creator A5088366490 @default.
- W2000394421 date "2002-02-07" @default.
- W2000394421 modified "2023-10-17" @default.
- W2000394421 title "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-κB signaling pathway" @default.
- W2000394421 cites W113625048 @default.
- W2000394421 cites W1480466711 @default.
- W2000394421 cites W1523963819 @default.
- W2000394421 cites W1585517331 @default.
- W2000394421 cites W1606885912 @default.
- W2000394421 cites W1617532721 @default.
- W2000394421 cites W1863238068 @default.
- W2000394421 cites W1947022122 @default.
- W2000394421 cites W1971915141 @default.
- W2000394421 cites W1972372608 @default.
- W2000394421 cites W1982297304 @default.
- W2000394421 cites W1983398917 @default.
- W2000394421 cites W1984418041 @default.
- W2000394421 cites W1991868611 @default.
- W2000394421 cites W1993163893 @default.
- W2000394421 cites W1993216157 @default.
- W2000394421 cites W1997954665 @default.
- W2000394421 cites W1998038367 @default.
- W2000394421 cites W2004078164 @default.
- W2000394421 cites W2004339917 @default.
- W2000394421 cites W2024306318 @default.
- W2000394421 cites W2026389696 @default.
- W2000394421 cites W2028281910 @default.
- W2000394421 cites W2032984787 @default.
- W2000394421 cites W2033801757 @default.
- W2000394421 cites W2040857227 @default.
- W2000394421 cites W2048121649 @default.
- W2000394421 cites W2053102794 @default.
- W2000394421 cites W2053174155 @default.
- W2000394421 cites W2053383702 @default.
- W2000394421 cites W2056270776 @default.
- W2000394421 cites W2058138221 @default.
- W2000394421 cites W2060538012 @default.
- W2000394421 cites W2068427129 @default.
- W2000394421 cites W2070001832 @default.
- W2000394421 cites W2071638516 @default.
- W2000394421 cites W2077673188 @default.
- W2000394421 cites W2091545748 @default.
- W2000394421 cites W2097767970 @default.
- W2000394421 cites W2115207474 @default.
- W2000394421 cites W2115732428 @default.
- W2000394421 cites W2119186515 @default.
- W2000394421 cites W2132097023 @default.
- W2000394421 cites W2141916872 @default.
- W2000394421 cites W2150418339 @default.
- W2000394421 cites W2150483305 @default.
- W2000394421 cites W2160680191 @default.
- W2000394421 cites W2169724245 @default.
- W2000394421 cites W2173344695 @default.
- W2000394421 cites W2322630375 @default.
- W2000394421 cites W2330700669 @default.
- W2000394421 cites W4248162981 @default.
- W2000394421 cites W4252217633 @default.
- W2000394421 cites W4292820908 @default.
- W2000394421 doi "https://doi.org/10.1038/sj.onc.1205154" @default.
- W2000394421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11850823" @default.
- W2000394421 hasPublicationYear "2002" @default.
- W2000394421 type Work @default.
- W2000394421 sameAs 2000394421 @default.
- W2000394421 citedByCount "49" @default.
- W2000394421 countsByYear W20003944212012 @default.
- W2000394421 countsByYear W20003944212013 @default.
- W2000394421 countsByYear W20003944212014 @default.
- W2000394421 countsByYear W20003944212015 @default.
- W2000394421 countsByYear W20003944212016 @default.
- W2000394421 countsByYear W20003944212017 @default.
- W2000394421 countsByYear W20003944212018 @default.
- W2000394421 countsByYear W20003944212019 @default.
- W2000394421 countsByYear W20003944212022 @default.
- W2000394421 crossrefType "journal-article" @default.
- W2000394421 hasAuthorship W2000394421A5010579783 @default.
- W2000394421 hasAuthorship W2000394421A5020115662 @default.
- W2000394421 hasAuthorship W2000394421A5042708757 @default.
- W2000394421 hasAuthorship W2000394421A5081065929 @default.
- W2000394421 hasAuthorship W2000394421A5088366490 @default.
- W2000394421 hasBestOaLocation W20003944211 @default.
- W2000394421 hasConcept C2776912716 @default.
- W2000394421 hasConcept C2777609662 @default.
- W2000394421 hasConcept C2778308172 @default.
- W2000394421 hasConcept C51785407 @default.
- W2000394421 hasConcept C55493867 @default.
- W2000394421 hasConcept C62112901 @default.
- W2000394421 hasConcept C62478195 @default.
- W2000394421 hasConcept C75217442 @default.
- W2000394421 hasConcept C86554907 @default.
- W2000394421 hasConcept C86803240 @default.
- W2000394421 hasConcept C95444343 @default.
- W2000394421 hasConceptScore W2000394421C2776912716 @default.