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• W2000395251 abstract "Cancer vaccines can induce robust activation of tumor-specific CD8+ T cells that can destroy tumors. Understanding the mechanism by which cancer vaccines work is essential in designing next-generation vaccines with more potent therapeutic activity. We recently reported that short peptides emulsified in poorly biodegradable, Incomplete Freund's Adjuvant (IFA) primed CD8+ T cells that did not localize to the tumor site but accumulated at the persisting, antigen-rich vaccination site. The vaccination site eventually became a T cell graveyard where T cells responded to chronically released gp100 peptide by releasing cytokines, including interferon-γ (IFN-γ), which in turn upregulated Fas ligand (FasL) on host cells, causing apoptosis of Fas+ T cells. T cells that escaped apoptosis rapidly became exhausted, memory formation was poor, and therapeutic impact was minimal. Replacing the non-biodegradable IFA-based formulation with water-based, short-lived formulation in the presence of immunostimulatory molecules allowed T cells to traffic to tumors, causing their regression. In this review, we discuss recent advances in immunotherapeutic approaches that could enhance vaccine-primed immune cells fitness and render the tumor microenvironment more accessible for immune cell infiltration." @default.
• W2000395251 created "2016-06-24" @default.
• W2000395251 creator A5044032746 @default.
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• W2000395251 date "2014-08-01" @default.
• W2000395251 modified "2023-09-23" @default.
• W2000395251 title "Cancer vaccines: Trafficking of tumor-specific T cells to tumor after therapeutic vaccination" @default.
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• W2000395251 doi "https://doi.org/10.1016/j.biocel.2014.04.019" @default.
• W2000395251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4111967" @default.
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