FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000396789> ?p ?o ?g. }

• W2000396789 endingPage "82" @default.
• W2000396789 startingPage "73" @default.
• W2000396789 abstract "Matrix metalloproteinase 9 (MMP-9) is a Zn(2+)-dependent endopeptidase that degrades some of the components of basement membranes and extracellular matrix and thus participates in leukocyte infiltration during inflammation. In a model of zymosan peritonitis, neutrophil infiltration in MMP-deficient (MMP-9(-/-)) mice was significantly weaker at the time of their maximal influx in wild-type mice (6h). However, during the late stages of peritonitis (24h) an extended accumulation of neutrophils was observed in MMP-9(-/-)versus the wild-type mice. Recently, we reported that the ratio of apoptosis of inflammatory leukocytes is impaired in MMP-9(-/-) mice during late peritonitis and the process depends on COX-1-driven PGE(2). Here we scrutinized the alterations in apoptotic mechanisms by comparisons between MMP-9(-/-) and the wild-type mice. Altered apoptosis occurred only during late (24h) peritonitis and concerned only neutrophils, and not macrophages, mast cells or lymphocytes. Furthermore, expression and activity of caspases was altered in MMP-9(-/-) animals, delayed for caspase-8 and -9, and decreased in the case of caspase-3. Also the expression of Bax/Bcl-2 proteins was changed in MMP-9(-/-) mice. These changes, and in particular the impaired neutrophil apoptosis and weaker caspase-3 activity, were restored by the selective COX-1 inhibition. We conclude that in mice lacking MMP-9 the enhanced COX-1-PGE(2) decreases caspase-3 expression and activity leading to impaired apoptosis of inflammatory neutrophils resulting in abnormal accumulation of the cells at the inflammatory focus. The data also reinforce the notion that MMP-9 is a key enzyme in neutrophil biology." @default.
• W2000396789 created "2016-06-24" @default.
• W2000396789 creator A5022950566 @default.
• W2000396789 creator A5041017692 @default.
• W2000396789 creator A5048493199 @default.
• W2000396789 creator A5059152432 @default.
• W2000396789 creator A5078148926 @default.
• W2000396789 date "2009-09-01" @default.
• W2000396789 modified "2023-10-12" @default.
• W2000396789 title "Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3" @default.
• W2000396789 cites W1488829562 @default.
• W2000396789 cites W1533075111 @default.
• W2000396789 cites W1592314518 @default.
• W2000396789 cites W1615273910 @default.
• W2000396789 cites W1974261989 @default.
• W2000396789 cites W1976831807 @default.
• W2000396789 cites W1987421318 @default.
• W2000396789 cites W1987825791 @default.
• W2000396789 cites W1988129426 @default.
• W2000396789 cites W1995836592 @default.
• W2000396789 cites W2001110380 @default.
• W2000396789 cites W2002945376 @default.
• W2000396789 cites W2005993855 @default.
• W2000396789 cites W2014035565 @default.
• W2000396789 cites W2016331817 @default.
• W2000396789 cites W2016411107 @default.
• W2000396789 cites W2026988411 @default.
• W2000396789 cites W2028883300 @default.
• W2000396789 cites W2039096622 @default.
• W2000396789 cites W2049652467 @default.
• W2000396789 cites W2054072076 @default.
• W2000396789 cites W2056870877 @default.
• W2000396789 cites W2057512153 @default.
• W2000396789 cites W2059450459 @default.
• W2000396789 cites W2066944027 @default.
• W2000396789 cites W2071890540 @default.
• W2000396789 cites W2072278321 @default.
• W2000396789 cites W2073259535 @default.
• W2000396789 cites W2079312819 @default.
• W2000396789 cites W2101189183 @default.
• W2000396789 cites W2109330502 @default.
• W2000396789 cites W2117985944 @default.
• W2000396789 cites W2125686203 @default.
• W2000396789 cites W2126262661 @default.
• W2000396789 cites W2129059285 @default.
• W2000396789 cites W2129965095 @default.
• W2000396789 cites W2135423586 @default.
• W2000396789 cites W2135677877 @default.
• W2000396789 cites W2149233326 @default.
• W2000396789 cites W2156263239 @default.
• W2000396789 cites W2163406329 @default.
• W2000396789 cites W2166963888 @default.
• W2000396789 cites W2168042201 @default.
• W2000396789 cites W2170080233 @default.
• W2000396789 cites W2271429882 @default.
• W2000396789 cites W2323139294 @default.
• W2000396789 cites W319674832 @default.
• W2000396789 doi "https://doi.org/10.1016/j.imlet.2009.08.002" @default.
• W2000396789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19682497" @default.
• W2000396789 hasPublicationYear "2009" @default.
• W2000396789 type Work @default.
• W2000396789 sameAs 2000396789 @default.
• W2000396789 citedByCount "21" @default.
• W2000396789 countsByYear W20003967892012 @default.
• W2000396789 countsByYear W20003967892013 @default.
• W2000396789 countsByYear W20003967892014 @default.
• W2000396789 countsByYear W20003967892015 @default.
• W2000396789 countsByYear W20003967892016 @default.
• W2000396789 countsByYear W20003967892017 @default.
• W2000396789 countsByYear W20003967892018 @default.
• W2000396789 crossrefType "journal-article" @default.
• W2000396789 hasAuthorship W2000396789A5022950566 @default.
• W2000396789 hasAuthorship W2000396789A5041017692 @default.
• W2000396789 hasAuthorship W2000396789A5048493199 @default.
• W2000396789 hasAuthorship W2000396789A5059152432 @default.
• W2000396789 hasAuthorship W2000396789A5078148926 @default.
• W2000396789 hasConcept C109523444 @default.
• W2000396789 hasConcept C121332964 @default.
• W2000396789 hasConcept C12519072 @default.
• W2000396789 hasConcept C126322002 @default.
• W2000396789 hasConcept C134018914 @default.
• W2000396789 hasConcept C134897094 @default.
• W2000396789 hasConcept C153400128 @default.
• W2000396789 hasConcept C185592680 @default.
• W2000396789 hasConcept C190283241 @default.
• W2000396789 hasConcept C202751555 @default.
• W2000396789 hasConcept C203014093 @default.
• W2000396789 hasConcept C2776914184 @default.
• W2000396789 hasConcept C2778870864 @default.
• W2000396789 hasConcept C2780199535 @default.
• W2000396789 hasConcept C31573885 @default.
• W2000396789 hasConcept C55493867 @default.
• W2000396789 hasConcept C71924100 @default.
• W2000396789 hasConcept C86803240 @default.
• W2000396789 hasConcept C95444343 @default.
• W2000396789 hasConcept C97355855 @default.
• W2000396789 hasConcept C98424977 @default.
• W2000396789 hasConceptScore W2000396789C109523444 @default.

• next