Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000398758> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000398758 abstract "C6 is a cell line that expresses glial and neuronal markers. Treatments that increase intracellular cAMP levels induce the differentiation of these cells. We had previously demonstrated that forskolin, an agent that activates adenylate cyclase, produced changes in gene expression in C6 cells. As a consequence of this treatment, glutamic acid decarboxylase (GAD) activity and the mRNA for GAD67, one of the isoforms of the enzyme, decreased. In contrast, this treatment increased the transcription of the glial fibrillary acidic protein (GFAP) gene. We now show, by immunocytochemistry, that the changes in gene expression are phenotypically reflected by corresponding changes in the levels of the proteins encoded by the GAD67 and GFAP genes. Computer-assisted image analysis demonstrated that both the increase in GFAP immunofluorescence, and the decrease in GAD67 immunofluorescence are statistically significant. The changes in gene expression and in protein immunoreactivity are part of the differentiation process of the C6 cells towards a more mature glial phenotype." @default.
- W2000398758 created "2016-06-24" @default.
- W2000398758 creator A5006162439 @default.
- W2000398758 creator A5022629209 @default.
- W2000398758 creator A5033952550 @default.
- W2000398758 date "1995-05-01" @default.
- W2000398758 modified "2023-09-25" @default.
- W2000398758 title "Intracellular increases of cAMP induce opposite effects in glutamic acid decarboxylase (GAD67) and glial fibrillary acidic protein immunoreactivities in C6 cells" @default.
- W2000398758 cites W1607927414 @default.
- W2000398758 cites W1964002146 @default.
- W2000398758 cites W1969436626 @default.
- W2000398758 cites W1971660465 @default.
- W2000398758 cites W1975577924 @default.
- W2000398758 cites W1979998480 @default.
- W2000398758 cites W1987308911 @default.
- W2000398758 cites W1987873158 @default.
- W2000398758 cites W1997284583 @default.
- W2000398758 cites W2000914909 @default.
- W2000398758 cites W2009942937 @default.
- W2000398758 cites W2012961291 @default.
- W2000398758 cites W2021893363 @default.
- W2000398758 cites W2035185214 @default.
- W2000398758 cites W2038472828 @default.
- W2000398758 cites W2040827984 @default.
- W2000398758 cites W2053031834 @default.
- W2000398758 cites W2068056267 @default.
- W2000398758 cites W2068420002 @default.
- W2000398758 cites W2092402263 @default.
- W2000398758 cites W2096441504 @default.
- W2000398758 cites W2165924603 @default.
- W2000398758 doi "https://doi.org/10.1016/0304-3940(95)11544-x" @default.
- W2000398758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7659299" @default.
- W2000398758 hasPublicationYear "1995" @default.
- W2000398758 type Work @default.
- W2000398758 sameAs 2000398758 @default.
- W2000398758 citedByCount "8" @default.
- W2000398758 countsByYear W20003987582018 @default.
- W2000398758 crossrefType "journal-article" @default.
- W2000398758 hasAuthorship W2000398758A5006162439 @default.
- W2000398758 hasAuthorship W2000398758A5022629209 @default.
- W2000398758 hasAuthorship W2000398758A5033952550 @default.
- W2000398758 hasConcept C104317684 @default.
- W2000398758 hasConcept C134018914 @default.
- W2000398758 hasConcept C150194340 @default.
- W2000398758 hasConcept C153911025 @default.
- W2000398758 hasConcept C159431405 @default.
- W2000398758 hasConcept C159654299 @default.
- W2000398758 hasConcept C181199279 @default.
- W2000398758 hasConcept C202751555 @default.
- W2000398758 hasConcept C203014093 @default.
- W2000398758 hasConcept C204232928 @default.
- W2000398758 hasConcept C2778236600 @default.
- W2000398758 hasConcept C2779276759 @default.
- W2000398758 hasConcept C2780495277 @default.
- W2000398758 hasConcept C35866371 @default.
- W2000398758 hasConcept C53345823 @default.
- W2000398758 hasConcept C55493867 @default.
- W2000398758 hasConcept C86803240 @default.
- W2000398758 hasConcept C9497952 @default.
- W2000398758 hasConcept C95444343 @default.
- W2000398758 hasConceptScore W2000398758C104317684 @default.
- W2000398758 hasConceptScore W2000398758C134018914 @default.
- W2000398758 hasConceptScore W2000398758C150194340 @default.
- W2000398758 hasConceptScore W2000398758C153911025 @default.
- W2000398758 hasConceptScore W2000398758C159431405 @default.
- W2000398758 hasConceptScore W2000398758C159654299 @default.
- W2000398758 hasConceptScore W2000398758C181199279 @default.
- W2000398758 hasConceptScore W2000398758C202751555 @default.
- W2000398758 hasConceptScore W2000398758C203014093 @default.
- W2000398758 hasConceptScore W2000398758C204232928 @default.
- W2000398758 hasConceptScore W2000398758C2778236600 @default.
- W2000398758 hasConceptScore W2000398758C2779276759 @default.
- W2000398758 hasConceptScore W2000398758C2780495277 @default.
- W2000398758 hasConceptScore W2000398758C35866371 @default.
- W2000398758 hasConceptScore W2000398758C53345823 @default.
- W2000398758 hasConceptScore W2000398758C55493867 @default.
- W2000398758 hasConceptScore W2000398758C86803240 @default.
- W2000398758 hasConceptScore W2000398758C9497952 @default.
- W2000398758 hasConceptScore W2000398758C95444343 @default.
- W2000398758 hasLocation W20003987581 @default.
- W2000398758 hasLocation W20003987582 @default.
- W2000398758 hasOpenAccess W2000398758 @default.
- W2000398758 hasPrimaryLocation W20003987581 @default.
- W2000398758 hasRelatedWork W1968074776 @default.
- W2000398758 hasRelatedWork W2000398758 @default.
- W2000398758 hasRelatedWork W2017103202 @default.
- W2000398758 hasRelatedWork W2043797153 @default.
- W2000398758 hasRelatedWork W2054154019 @default.
- W2000398758 hasRelatedWork W2064683269 @default.
- W2000398758 hasRelatedWork W2327294438 @default.
- W2000398758 hasRelatedWork W1971105892 @default.
- W2000398758 hasRelatedWork W2079270745 @default.
- W2000398758 hasRelatedWork W2079397396 @default.
- W2000398758 isParatext "false" @default.
- W2000398758 isRetracted "false" @default.
- W2000398758 magId "2000398758" @default.
- W2000398758 workType "article" @default.