FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000399377> ?p ?o ?g. }

• W2000399377 endingPage "296" @default.
• W2000399377 startingPage "285" @default.
• W2000399377 abstract "Abstract Attentional dysfunction is a persistent behavioral abnormality that is emerging as one of the cardinal features in the investigations of the teratogenic effects of cocaine in humans and rodents. The present study sought to extend this work by using a dose–response design with an alternate strain of rat. Virgin Long–Evans female rats, implanted with an IV access port prior to breeding were administered saline, 0.5, 1.0, or 3.0 mg/kg of cocaine HCl from gestational day (GD) GD8–21 (1× per day‐GD8–14, 2× per day‐GD15–21). Cocaine had no significant effect on maternal or litter parameters. At 14–15 days of age, 1 male and 1 female from each litter were tested to evaluate the heart rate orienting response (HR‐OR). Following 20 min for acclimation, pups were presented an olfactory stimulus for 20 s per trial, across four trials, and with an intertrial interval of 2 min. The initial baseline HR was not significantly different across the treatment groups, although cocaine did alter the stability of the QRS complex duration. The magnitude of the HR‐OR averaged across trials increased as a linear function of dosage of cocaine. A more complex (quadratic) interaction between cocaine dose and sex of the offspring was also noted. When examined across trials, the controls failed to display any significant within‐session variation in the HR‐OR; in contrast all of the prenatal cocaine treated groups displayed either sensitization (low and high dose) or habituation of the response (middle dose). Analysis of the peak HR‐OR confirmed that the controls were indeed displaying the response on at least one trial of the session, albeit not consistently on any specific trial. The more vigorous HR‐OR of the prenatal cocaine groups, relative to vehicle controls, most likely reflects an alteration in development of the neural basis of response; as previously shown, the most vigorous response to the olfactory stimulus is seen early (12 days of age) and progressively decreases across the preweaning period. In sum, prenatal exposure to cocaine, at least when administered by the IV route, provides reproducible alterations in attentional processes, as indexed by the noradrenergically‐mediated HR‐OR. The documentation of a linear dose–response function suggests that there is likely no threshold for the drug‐induced alteration. Moreover, the sex of the animal also appears to play some role in the nature of the expression of the altered HR‐OR." @default.
• W2000399377 created "2016-06-24" @default.
• W2000399377 creator A5020916882 @default.
• W2000399377 creator A5029143320 @default.
• W2000399377 creator A5047436104 @default.
• W2000399377 creator A5058111972 @default.
• W2000399377 creator A5078130206 @default.
• W2000399377 date "2004-08-01" @default.
• W2000399377 modified "2023-10-15" @default.
• W2000399377 title "Prenatal intravenous cocaine and the heart rate‐orienting response: a dose–response study" @default.
• W2000399377 cites W1188479996 @default.
• W2000399377 cites W138330660 @default.
• W2000399377 cites W1574760783 @default.
• W2000399377 cites W1872569578 @default.
• W2000399377 cites W1954301870 @default.
• W2000399377 cites W1964042094 @default.
• W2000399377 cites W1965391811 @default.
• W2000399377 cites W1966388059 @default.
• W2000399377 cites W1967473292 @default.
• W2000399377 cites W1967908924 @default.
• W2000399377 cites W1974587599 @default.
• W2000399377 cites W1977050804 @default.
• W2000399377 cites W1980205437 @default.
• W2000399377 cites W1981902992 @default.
• W2000399377 cites W1983311090 @default.
• W2000399377 cites W1983548799 @default.
• W2000399377 cites W1983775298 @default.
• W2000399377 cites W1988030321 @default.
• W2000399377 cites W1989030766 @default.
• W2000399377 cites W1989062816 @default.
• W2000399377 cites W1990249341 @default.
• W2000399377 cites W1991005069 @default.
• W2000399377 cites W1996264060 @default.
• W2000399377 cites W1996709582 @default.
• W2000399377 cites W1998896933 @default.
• W2000399377 cites W2000544412 @default.
• W2000399377 cites W2001497476 @default.
• W2000399377 cites W2006056828 @default.
• W2000399377 cites W2016415469 @default.
• W2000399377 cites W2026554786 @default.
• W2000399377 cites W2026896579 @default.
• W2000399377 cites W2027229658 @default.
• W2000399377 cites W2034894288 @default.
• W2000399377 cites W2037744707 @default.
• W2000399377 cites W2038731052 @default.
• W2000399377 cites W2050034637 @default.
• W2000399377 cites W2051604643 @default.
• W2000399377 cites W2053230264 @default.
• W2000399377 cites W2055380459 @default.
• W2000399377 cites W2057712301 @default.
• W2000399377 cites W2059912751 @default.
• W2000399377 cites W2060816711 @default.
• W2000399377 cites W2062526841 @default.
• W2000399377 cites W2065269006 @default.
• W2000399377 cites W2065529097 @default.
• W2000399377 cites W2066661887 @default.
• W2000399377 cites W2067735524 @default.
• W2000399377 cites W2071203891 @default.
• W2000399377 cites W2078805684 @default.
• W2000399377 cites W2079643882 @default.
• W2000399377 cites W2081336408 @default.
• W2000399377 cites W2085234146 @default.
• W2000399377 cites W2088305437 @default.
• W2000399377 cites W2092653249 @default.
• W2000399377 cites W2095577298 @default.
• W2000399377 cites W2115244559 @default.
• W2000399377 cites W2146591616 @default.
• W2000399377 cites W2153014114 @default.
• W2000399377 cites W2154511754 @default.
• W2000399377 cites W4230051814 @default.
• W2000399377 cites W4230909626 @default.
• W2000399377 cites W4234685833 @default.
• W2000399377 cites W4243234584 @default.
• W2000399377 cites W4243524291 @default.
• W2000399377 cites W4244404394 @default.
• W2000399377 cites W4256150991 @default.
• W2000399377 cites W4293082421 @default.
• W2000399377 cites W4298164506 @default.
• W2000399377 cites W86028312 @default.
• W2000399377 doi "https://doi.org/10.1016/j.ijdevneu.2004.05.010" @default.
• W2000399377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15380828" @default.
• W2000399377 hasPublicationYear "2004" @default.
• W2000399377 type Work @default.
• W2000399377 sameAs 2000399377 @default.
• W2000399377 citedByCount "16" @default.
• W2000399377 countsByYear W20003993772013 @default.
• W2000399377 countsByYear W20003993772015 @default.
• W2000399377 countsByYear W20003993772020 @default.
• W2000399377 crossrefType "journal-article" @default.
• W2000399377 hasAuthorship W2000399377A5020916882 @default.
• W2000399377 hasAuthorship W2000399377A5029143320 @default.
• W2000399377 hasAuthorship W2000399377A5047436104 @default.
• W2000399377 hasAuthorship W2000399377A5058111972 @default.
• W2000399377 hasAuthorship W2000399377A5078130206 @default.
• W2000399377 hasConcept C112672928 @default.
• W2000399377 hasConcept C126322002 @default.
• W2000399377 hasConcept C15744967 @default.
• W2000399377 hasConcept C169760540 @default.

• next