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- W2000401952 abstract "So far, only a few retrovirus-like transposable elements (TEs) have been reported in Anopheles mosquitoes, although a large fraction of their genomes is made up of these middle repetitive sequences. By screening the A. gambiae genome databases, we have found 10 element families belonging to the mdg1 lineage of the Ty3/gypsy group of long terminal repeat (LTR) retrotransposons. These Anopheles families constitute a sister clade of the Drosophila representatives of this same lineage. According to the phylogenetic reconstruction of their open reading frame (ORF)2 enzymatic domains, the analysis of patterns of nucleotide substitution therein, and the estimation of the age of particular insertions, all these elements must have been active until quite recently, and some of them must be very young. On the other hand, the fact that all these element families are primarily composed of fragmentary copies (mostly solos) or full-length copies with inactivating mutations indicates that their turnover rate has been probably very low. Finally, incongruent phylogenies obtained from different regions of the elements strongly suggest that recombination has played a significant role in their evolutionary history." @default.
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- W2000401952 date "2004-04-01" @default.
- W2000401952 modified "2023-09-28" @default.
- W2000401952 title "Evolution of the mdg1 lineage of the Ty3/gypsy group of LTR retrotransposons in Anopheles gambiae" @default.
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- W2000401952 doi "https://doi.org/10.1016/j.gene.2004.01.012" @default.
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