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- W2000401960 abstract "Two-day-old rats injected intragastrically (i.g.) with 238Pu nitrate absorb about 100 times more 238Pu than adult animals. The mucosa of the small intestine retains about 10 times more Pu than is absorbed during the first week after gavage. To determine if chelate therapy is effective for removing deposited Pu or Pu retained in the mucosa, groups of rats were given 238Pu intragastrically and then treated with Ca-DTPA, either i.g. or parenterally, 2 hours (prompt) or 5 days (delayed) later. When the rats were killed, we found that the 238Pu in the intestine was reduced from 18% of the Pu dose to about 2% by prompt treatment. Delayed treatment also reduced the amount in the gastrointestinal (GI) tract, to about 15% of untreated controls. Although DTPA is not well absorbed from the GI tract of adult rats, it was about as effective for removing Pu from the neonate when given by gavage as it was when given parenterally. Prompt DTPA treatment reduced the quantity of 238Pu retained in the skeleton, liver and soft tissue to about one-third of the untreated control value; delayed treatment reduced it to about one-half the control value. Treatment by the parenteral route was more effective for removing Pu from bone. The results suggest that 238Pu retained in the mucosa of the GI tract is loosely bound; consequently, chelate therapy is more effective in the GI tract than in the skeleton, where the 238Pu retained is more firmly bound." @default.
- W2000401960 created "2016-06-24" @default.
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- W2000401960 date "1984-04-01" @default.
- W2000401960 modified "2023-09-25" @default.
- W2000401960 title "REMOVAL OF PLUTONIUM FROM NEONATAL RATS BY CHELATION THERAPY" @default.
- W2000401960 doi "https://doi.org/10.1203/00006450-198404001-00726" @default.
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