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- W2000402766 abstract "Complex gene networks are responsible for the proper operation of the endocrine pancreas. A central member of such networks, the homeodomain transcription factor Pdx1, belongs to the ParaHox gene cluster, an array of Hox-like homeobox genes. With a combination of mRNA in situ hybridisation and immunodetection, we have found that the rest of ParaHox cluster genes, Cdx1, Cdx2/3, and Cdx4, and Gsh1 and Gsh2, are all expressed in specific islet cell types of the endocrine pancreas. To our knowledge, this is the first report that locates ParaHox genes other than Pdx1 and Cdx2/3 in a place as to be involved in the pancreatic transcriptional regulatory networks, potentially regulating glucagon-insulin homeostasis." @default.
- W2000402766 created "2016-06-24" @default.
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- W2000402766 date "2005-06-01" @default.
- W2000402766 modified "2023-10-18" @default.
- W2000402766 title "Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets" @default.
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- W2000402766 doi "https://doi.org/10.1016/j.mce.2005.03.008" @default.
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