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- W2000402945 abstract "Phosphoribosylpyrophosphate (PP-Rib-P) is a key regulator of de. novo purine synthesis and because of the kinetic properties of glutamine amido-phosphoribosyltransferase, small changes in the intracellular concentration of PP-Rib-P can cause major changes in rates of de novo purine synthesis (1). We recently showed that ribose 5-phosphate (Rib-5-P), the immediate precursor of PP-Rib-P may also be rate-limiting for de novo purine synthesis in human lymphoblasts, since its intracellular concentration is well below the Km of PP-Rib-P synthetase for this substrate at physiological phosphate concentrations (2, 3).KeywordsPentose Phosphate PathwayCarbon FlowAmino Acid StarvationOxidative Pentose Phosphate PathwayPurine SynthesisThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W2000402945 date "1986-01-01" @default.
- W2000402945 modified "2023-09-27" @default.
- W2000402945 title "The Synthesis of Phosphoribosylpyrophosphate from Glucose Decreases During Amino Acid Starvation of Human Lymphoblasts" @default.
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- W2000402945 doi "https://doi.org/10.1007/978-1-4684-1248-2_95" @default.
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