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- W2000403320 abstract "1. Rat plasma corticosterone increases during 2 hr restraint stress. The animals then exhibit hypophagia and decreased locomotion occurs on placement 24 hr later in an open field. Repeating the restraint daily for 5–7 days leads to adaptation. Failure to adapt is the depression model which is associated with three factors implicated in the illness is increased plasma glucocorticoid level, female sex and inadequate 5-HT function as revealed by behavioural response to the agonist 5-methoxy-N,N-dimethyl 5-HT. However, the greater stress induced rise of corticosterone in female rats may reflect a greater response to activation of hypothalamic 5-HT receptors mediating corticoid release. 2. The model responds appropriately to chronic antidepressant pretreatment. Single injections of 5-HT1A, agonists (8-OH-DPAT, buspirone, ipsapirone, gepirone) but not of benzodiazepine anxiolytics have similar effects. Therefore, 5-HT1A, agonists may have antidepressant activity. Both behavioural and neurochemical evidence indicates that the adaptive effects of 5-HT1A, agonists on the depression model are associated with desensitisation of somatodendritic 5-HT1A autoreceptors." @default.
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- W2000403320 date "1989-01-01" @default.
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- W2000403320 title "5-Hydroxytryptamine and corticosterone in an animal model of depression" @default.
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- W2000403320 doi "https://doi.org/10.1016/0278-5846(89)90119-x" @default.
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