FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000405871> ?p ?o ?g. }

• W2000405871 endingPage "600" @default.
• W2000405871 startingPage "595" @default.
• W2000405871 abstract "Abstract Protein expression of p63 is used to differentiate prostate cancer from benign mimickers. Recent studies suggest that it may also distinguish aggressive prostate cancer with down-regulated expression occurring in men with more advanced disease. We conducted a prospective study among 298 men ages 51 to 84 years who were diagnosed with prostate cancer in the Physicians' Health Study in 1983 to 2004 and whose tissue was available for immunohistochemical staining. We used Cox proportional hazards regression to evaluate the association of p63 protein expression with fatal prostate cancer. We correlated p63 expression with tumor cell proliferation (Ki-67) and apoptosis (TUNEL staining). The predominant location of tumor p63 staining occurred in the cytoplasm, an uncommon departure from the strong nuclear staining usually observed in nonneoplastic basal cells. Increasing expression of cytoplasmic p63 (tertiles) was associated with prostate cancer mortality (n = 19 deaths); the hazard ratios (95% confidence intervals) were 1.0 (reference), 4.0 (0.9-18.9), and 5.9 (1.3-27.5; Ptrend = 0.03). The positive trend remained significant (P = 0.047) after multivariable adjustment for age, year of diagnosis, and Gleason score. Higher tertiles of cytoplasmic p63 were also associated with reduced levels of apoptosis (Ptrend = 0.0408) and increased cellular proliferation (Ptrend = 0.0026). We found aberrant expression of p63 in the cytoplasm to be associated with increased prostate cancer-specific mortality up to 20 years after diagnosis. The mislocalized expression was associated with reduced apoptosis and higher proliferative activity and may suggest an oncogenic role in prostate cancer progression and survival. (Cancer Epidemiol Biomarkers Prev 2009;18(2):595–600)" @default.
• W2000405871 created "2016-06-24" @default.
• W2000405871 creator A5011935671 @default.
• W2000405871 creator A5035068594 @default.
• W2000405871 creator A5035595122 @default.
• W2000405871 creator A5044562854 @default.
• W2000405871 creator A5049753330 @default.
• W2000405871 creator A5059155373 @default.
• W2000405871 creator A5067413533 @default.
• W2000405871 creator A5068738028 @default.
• W2000405871 creator A5076393453 @default.
• W2000405871 creator A5077189352 @default.
• W2000405871 creator A5081569621 @default.
• W2000405871 date "2009-02-01" @default.
• W2000405871 modified "2023-10-01" @default.
• W2000405871 title "Aberrant Cytoplasmic Expression of p63 and Prostate Cancer Mortality" @default.
• W2000405871 cites W1482923899 @default.
• W2000405871 cites W1746080159 @default.
• W2000405871 cites W1970135335 @default.
• W2000405871 cites W1980569612 @default.
• W2000405871 cites W1981070518 @default.
• W2000405871 cites W1982121839 @default.
• W2000405871 cites W1988336550 @default.
• W2000405871 cites W1997406677 @default.
• W2000405871 cites W1997646834 @default.
• W2000405871 cites W1999678872 @default.
• W2000405871 cites W2014938226 @default.
• W2000405871 cites W2016731068 @default.
• W2000405871 cites W2017801403 @default.
• W2000405871 cites W2018391923 @default.
• W2000405871 cites W2030112489 @default.
• W2000405871 cites W2045780505 @default.
• W2000405871 cites W2051409222 @default.
• W2000405871 cites W2053535373 @default.
• W2000405871 cites W2054188457 @default.
• W2000405871 cites W2058815669 @default.
• W2000405871 cites W2062612693 @default.
• W2000405871 cites W2073681698 @default.
• W2000405871 cites W2076118650 @default.
• W2000405871 cites W2080851462 @default.
• W2000405871 cites W2082979850 @default.
• W2000405871 cites W2084499599 @default.
• W2000405871 cites W2087299009 @default.
• W2000405871 cites W2101185543 @default.
• W2000405871 cites W2116998164 @default.
• W2000405871 cites W2117249292 @default.
• W2000405871 cites W2132408182 @default.
• W2000405871 cites W2132907440 @default.
• W2000405871 cites W2138863804 @default.
• W2000405871 cites W2140159951 @default.
• W2000405871 cites W2150507760 @default.
• W2000405871 cites W2150554965 @default.
• W2000405871 cites W2164594843 @default.
• W2000405871 cites W2166213130 @default.
• W2000405871 cites W2335695853 @default.
• W2000405871 cites W4245466284 @default.
• W2000405871 doi "https://doi.org/10.1158/1055-9965.epi-08-0785" @default.
• W2000405871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692093" @default.
• W2000405871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19155438" @default.
• W2000405871 hasPublicationYear "2009" @default.
• W2000405871 type Work @default.
• W2000405871 sameAs 2000405871 @default.
• W2000405871 citedByCount "59" @default.
• W2000405871 countsByYear W20004058712012 @default.
• W2000405871 countsByYear W20004058712013 @default.
• W2000405871 countsByYear W20004058712014 @default.
• W2000405871 countsByYear W20004058712015 @default.
• W2000405871 countsByYear W20004058712016 @default.
• W2000405871 countsByYear W20004058712018 @default.
• W2000405871 countsByYear W20004058712019 @default.
• W2000405871 countsByYear W20004058712020 @default.
• W2000405871 countsByYear W20004058712021 @default.
• W2000405871 countsByYear W20004058712022 @default.
• W2000405871 countsByYear W20004058712023 @default.
• W2000405871 crossrefType "journal-article" @default.
• W2000405871 hasAuthorship W2000405871A5011935671 @default.
• W2000405871 hasAuthorship W2000405871A5035068594 @default.
• W2000405871 hasAuthorship W2000405871A5035595122 @default.
• W2000405871 hasAuthorship W2000405871A5044562854 @default.
• W2000405871 hasAuthorship W2000405871A5049753330 @default.
• W2000405871 hasAuthorship W2000405871A5059155373 @default.
• W2000405871 hasAuthorship W2000405871A5067413533 @default.
• W2000405871 hasAuthorship W2000405871A5068738028 @default.
• W2000405871 hasAuthorship W2000405871A5076393453 @default.
• W2000405871 hasAuthorship W2000405871A5077189352 @default.
• W2000405871 hasAuthorship W2000405871A5081569621 @default.
• W2000405871 hasBestOaLocation W20004058711 @default.
• W2000405871 hasConcept C121608353 @default.
• W2000405871 hasConcept C126322002 @default.
• W2000405871 hasConcept C142724271 @default.
• W2000405871 hasConcept C143998085 @default.
• W2000405871 hasConcept C190062978 @default.
• W2000405871 hasConcept C190283241 @default.
• W2000405871 hasConcept C196795494 @default.
• W2000405871 hasConcept C204232928 @default.
• W2000405871 hasConcept C207103383 @default.
• W2000405871 hasConcept C2776235491 @default.
• W2000405871 hasConcept C2780192828 @default.

• next