FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000406511> ?p ?o ?g. }

• W2000406511 endingPage "220" @default.
• W2000406511 startingPage "211" @default.
• W2000406511 abstract "Pharmacological activation of muscarinic receptors located in the thoracic spinal cord evokes a marked increase in blood pressure and heart rate. We have previously demonstrated that the cardiovascular response to stimulation of spinal cord muscarinic cholinergic receptors is dependent upon a pharmacologically described ascending spino-bulbar pathway. The purpose of the study was to determine whether the blood pressure and heart rate responses to intrathecal (i.t.) injection of the muscarinic cholinergic receptor agonist carbachol are mediated by a local nitric oxide (NO)-generating system. Freely moving rats were previously prepared with chronic indwelling i.t. and intra-arterial catheters. Both the pressor and tachycardic responses produced by i.t. injection of carbachol were inhibited in a dose-dependent manner by i.t. pre-treatment with the NO synthase inhibitor N-omega-Nitro-L-arginine methylester (L-NAME). To confirm the site of action of the drugs employed in conscious rats, a separate group of rats was anesthetized, and using surgical procedures previously developed in this laboratory, drug distribution was limited specifically to the lower thoracic spinal cord. When carbachol was administered by i.t. injection and localized to the lower thoracic area, muscarinic cholinergic receptor stimulation again produced a marked pressor response, but without the accompanying tachycardia. The ability of N-omega-Nitro-L-arginine methylester (L-NAME) to inhibit the pressor response to carbachol in conscious rats was confirmed in anesthetized rats, although higher doses of L-NAME than those employed in conscious rats were required. L-NAME-induced inhibition of the carbachol-evoked pressor response was reversed by the L-, but not the D-isomer, of arginine. Moreover, i.t. pre-treatment with Methylene blue, that interferes with NO production and function, effectively inhibited the expression of the pressor response to i.t. injection of carbachol. The 'anti-muscarinic' action of L-NAME was not due to a direct interaction with spinal muscarinic receptors, as L-NAME did not significantly displace [3H]methyl-scopolamine from spinal cord membranes in vitro. The results of this study support the hypothesis that spinal muscarinic cholinergic receptors participate in a sympathoexcitatory pathway that interacts either directly or indirectly with a local NO-generating system involved in the regulation of blood pressure." @default.
• W2000406511 created "2016-06-24" @default.
• W2000406511 creator A5005111714 @default.
• W2000406511 creator A5028964250 @default.
• W2000406511 creator A5035688947 @default.
• W2000406511 date "1996-10-01" @default.
• W2000406511 modified "2023-10-12" @default.
• W2000406511 title "Spinal muscarinic cholinergic and nitric oxide systems in cardiovascular regulation" @default.
• W2000406511 cites W1633849959 @default.
• W2000406511 cites W1971005608 @default.
• W2000406511 cites W1977423694 @default.
• W2000406511 cites W1986619455 @default.
• W2000406511 cites W1993135203 @default.
• W2000406511 cites W1995418515 @default.
• W2000406511 cites W1999675972 @default.
• W2000406511 cites W2006378474 @default.
• W2000406511 cites W2007737411 @default.
• W2000406511 cites W2009569170 @default.
• W2000406511 cites W2012785481 @default.
• W2000406511 cites W2023742522 @default.
• W2000406511 cites W2026171589 @default.
• W2000406511 cites W2031383268 @default.
• W2000406511 cites W2051344336 @default.
• W2000406511 cites W2053916008 @default.
• W2000406511 cites W2060761128 @default.
• W2000406511 cites W2063864239 @default.
• W2000406511 cites W2069174503 @default.
• W2000406511 cites W2071179154 @default.
• W2000406511 cites W2072112508 @default.
• W2000406511 cites W2090108559 @default.
• W2000406511 cites W2092088893 @default.
• W2000406511 cites W2097862969 @default.
• W2000406511 cites W2118571380 @default.
• W2000406511 cites W2147944067 @default.
• W2000406511 cites W2153615786 @default.
• W2000406511 cites W2169182236 @default.
• W2000406511 cites W2179702494 @default.
• W2000406511 doi "https://doi.org/10.1016/0014-2999(96)00513-4" @default.
• W2000406511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8911917" @default.
• W2000406511 hasPublicationYear "1996" @default.
• W2000406511 type Work @default.
• W2000406511 sameAs 2000406511 @default.
• W2000406511 citedByCount "18" @default.
• W2000406511 countsByYear W20004065112014 @default.
• W2000406511 countsByYear W20004065112021 @default.
• W2000406511 countsByYear W20004065112023 @default.
• W2000406511 crossrefType "journal-article" @default.
• W2000406511 hasAuthorship W2000406511A5005111714 @default.
• W2000406511 hasAuthorship W2000406511A5028964250 @default.
• W2000406511 hasAuthorship W2000406511A5035688947 @default.
• W2000406511 hasConcept C118552586 @default.
• W2000406511 hasConcept C126322002 @default.
• W2000406511 hasConcept C134018914 @default.
• W2000406511 hasConcept C170493617 @default.
• W2000406511 hasConcept C185592680 @default.
• W2000406511 hasConcept C22885893 @default.
• W2000406511 hasConcept C24998067 @default.
• W2000406511 hasConcept C2775859210 @default.
• W2000406511 hasConcept C2778938600 @default.
• W2000406511 hasConcept C2778988552 @default.
• W2000406511 hasConcept C2780775167 @default.
• W2000406511 hasConcept C33789571 @default.
• W2000406511 hasConcept C42219234 @default.
• W2000406511 hasConcept C519581460 @default.
• W2000406511 hasConcept C71924100 @default.
• W2000406511 hasConceptScore W2000406511C118552586 @default.
• W2000406511 hasConceptScore W2000406511C126322002 @default.
• W2000406511 hasConceptScore W2000406511C134018914 @default.
• W2000406511 hasConceptScore W2000406511C170493617 @default.
• W2000406511 hasConceptScore W2000406511C185592680 @default.
• W2000406511 hasConceptScore W2000406511C22885893 @default.
• W2000406511 hasConceptScore W2000406511C24998067 @default.
• W2000406511 hasConceptScore W2000406511C2775859210 @default.
• W2000406511 hasConceptScore W2000406511C2778938600 @default.
• W2000406511 hasConceptScore W2000406511C2778988552 @default.
• W2000406511 hasConceptScore W2000406511C2780775167 @default.
• W2000406511 hasConceptScore W2000406511C33789571 @default.
• W2000406511 hasConceptScore W2000406511C42219234 @default.
• W2000406511 hasConceptScore W2000406511C519581460 @default.
• W2000406511 hasConceptScore W2000406511C71924100 @default.
• W2000406511 hasIssue "3" @default.
• W2000406511 hasLocation W20004065111 @default.
• W2000406511 hasLocation W20004065112 @default.
• W2000406511 hasOpenAccess W2000406511 @default.
• W2000406511 hasPrimaryLocation W20004065111 @default.
• W2000406511 hasRelatedWork W1983631318 @default.
• W2000406511 hasRelatedWork W2022963038 @default.
• W2000406511 hasRelatedWork W2033000514 @default.
• W2000406511 hasRelatedWork W2053342558 @default.
• W2000406511 hasRelatedWork W2071365560 @default.
• W2000406511 hasRelatedWork W2074937555 @default.
• W2000406511 hasRelatedWork W2116785246 @default.
• W2000406511 hasRelatedWork W2136653410 @default.
• W2000406511 hasRelatedWork W2404861639 @default.
• W2000406511 hasRelatedWork W2761353431 @default.
• W2000406511 hasVolume "313" @default.
• W2000406511 isParatext "false" @default.
• W2000406511 isRetracted "false" @default.

• next