Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000408838> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2000408838 endingPage "1240" @default.
- W2000408838 startingPage "1235" @default.
- W2000408838 abstract "Behavior, even in simple metazoans, depends upon integrated processes at the subcellular, cellular, and organismal level, and thus is susceptible to disruption by a broad spectrum of chemicals. Locomotor behavior (movement) of the small free-living nematode Caenorhabditis elegans has proven to be useful in assessing toxicity. Recently reported observations suggest that behavioral change (reduced movement) occurs after 4 h of exposure to heavy metals, and that with abbreviated exposure, the concentration-response relationship for Pb (a known neurotoxic metal) differs from that for Cu. In this study, movement was evaluated after 4-h exposures for nine compounds from three chemical classes: organic pesticides, organic solvents, and heavy metals. Concentration-dependent reduction of movement was observed for all test compounds with the exception of mebendazole, for which test concentrations were limited by solubility. Within each chemical class, movement was more sensitive to the neurotoxic compounds than to substances not believed to be neurotoxic, as evidenced by behavioral effective concentration to reduce average worm movement to 50% of the control movement values (e.g., levamisole and chlorpyrifos < mebendazole, ethanol and acetone < dimethylsulfoxide, and Pb and Al < Cu). These observations are discussed as they relate to the use of acute behavioral tests in assessing general chemical toxicity, and the enhanced value of 4-h testing for the detection of neural toxicants." @default.
- W2000408838 created "2016-06-24" @default.
- W2000408838 creator A5029107620 @default.
- W2000408838 creator A5032269987 @default.
- W2000408838 creator A5044643998 @default.
- W2000408838 date "2004-05-01" @default.
- W2000408838 modified "2023-10-15" @default.
- W2000408838 title "Assessing behavioral toxicity with <i>Caenorhabditis elegans</i>" @default.
- W2000408838 cites W1944127002 @default.
- W2000408838 cites W1996418402 @default.
- W2000408838 cites W2050178612 @default.
- W2000408838 cites W2067339218 @default.
- W2000408838 cites W2085260316 @default.
- W2000408838 cites W2089799301 @default.
- W2000408838 cites W2090568255 @default.
- W2000408838 cites W2139208773 @default.
- W2000408838 cites W2154012864 @default.
- W2000408838 cites W2170873948 @default.
- W2000408838 doi "https://doi.org/10.1897/03-264" @default.
- W2000408838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15180374" @default.
- W2000408838 hasPublicationYear "2004" @default.
- W2000408838 type Work @default.
- W2000408838 sameAs 2000408838 @default.
- W2000408838 citedByCount "132" @default.
- W2000408838 countsByYear W20004088382012 @default.
- W2000408838 countsByYear W20004088382013 @default.
- W2000408838 countsByYear W20004088382014 @default.
- W2000408838 countsByYear W20004088382015 @default.
- W2000408838 countsByYear W20004088382016 @default.
- W2000408838 countsByYear W20004088382017 @default.
- W2000408838 countsByYear W20004088382018 @default.
- W2000408838 countsByYear W20004088382019 @default.
- W2000408838 countsByYear W20004088382020 @default.
- W2000408838 countsByYear W20004088382021 @default.
- W2000408838 countsByYear W20004088382022 @default.
- W2000408838 countsByYear W20004088382023 @default.
- W2000408838 crossrefType "journal-article" @default.
- W2000408838 hasAuthorship W2000408838A5029107620 @default.
- W2000408838 hasAuthorship W2000408838A5032269987 @default.
- W2000408838 hasAuthorship W2000408838A5044643998 @default.
- W2000408838 hasConcept C104317684 @default.
- W2000408838 hasConcept C104488531 @default.
- W2000408838 hasConcept C107872376 @default.
- W2000408838 hasConcept C116263406 @default.
- W2000408838 hasConcept C161176658 @default.
- W2000408838 hasConcept C178790620 @default.
- W2000408838 hasConcept C185592680 @default.
- W2000408838 hasConcept C18903297 @default.
- W2000408838 hasConcept C2776304672 @default.
- W2000408838 hasConcept C2778944004 @default.
- W2000408838 hasConcept C2779491297 @default.
- W2000408838 hasConcept C2780373086 @default.
- W2000408838 hasConcept C29730261 @default.
- W2000408838 hasConcept C33070731 @default.
- W2000408838 hasConcept C55493867 @default.
- W2000408838 hasConcept C86803240 @default.
- W2000408838 hasConceptScore W2000408838C104317684 @default.
- W2000408838 hasConceptScore W2000408838C104488531 @default.
- W2000408838 hasConceptScore W2000408838C107872376 @default.
- W2000408838 hasConceptScore W2000408838C116263406 @default.
- W2000408838 hasConceptScore W2000408838C161176658 @default.
- W2000408838 hasConceptScore W2000408838C178790620 @default.
- W2000408838 hasConceptScore W2000408838C185592680 @default.
- W2000408838 hasConceptScore W2000408838C18903297 @default.
- W2000408838 hasConceptScore W2000408838C2776304672 @default.
- W2000408838 hasConceptScore W2000408838C2778944004 @default.
- W2000408838 hasConceptScore W2000408838C2779491297 @default.
- W2000408838 hasConceptScore W2000408838C2780373086 @default.
- W2000408838 hasConceptScore W2000408838C29730261 @default.
- W2000408838 hasConceptScore W2000408838C33070731 @default.
- W2000408838 hasConceptScore W2000408838C55493867 @default.
- W2000408838 hasConceptScore W2000408838C86803240 @default.
- W2000408838 hasIssue "5" @default.
- W2000408838 hasLocation W20004088381 @default.
- W2000408838 hasLocation W20004088382 @default.
- W2000408838 hasOpenAccess W2000408838 @default.
- W2000408838 hasPrimaryLocation W20004088381 @default.
- W2000408838 hasRelatedWork W2020127060 @default.
- W2000408838 hasRelatedWork W2282958444 @default.
- W2000408838 hasRelatedWork W2350369235 @default.
- W2000408838 hasRelatedWork W2369774671 @default.
- W2000408838 hasRelatedWork W2384242396 @default.
- W2000408838 hasRelatedWork W2408511765 @default.
- W2000408838 hasRelatedWork W3152336119 @default.
- W2000408838 hasRelatedWork W3164628455 @default.
- W2000408838 hasRelatedWork W4313474347 @default.
- W2000408838 hasRelatedWork W2547701664 @default.
- W2000408838 hasVolume "23" @default.
- W2000408838 isParatext "false" @default.
- W2000408838 isRetracted "false" @default.
- W2000408838 magId "2000408838" @default.
- W2000408838 workType "article" @default.