Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000409509> ?p ?o ?g. }
- W2000409509 endingPage "2283" @default.
- W2000409509 startingPage "2266" @default.
- W2000409509 abstract "The human liver fatty acid‐binding protein (L‐ FABP ) T94A variant, the most common in the FABP family, has been associated with elevated liver triglyceride levels. How this amino acid substitution elicits these effects is not known. This issue was addressed using human recombinant wild‐type ( WT ) and T94A variant L‐ FABP proteins as well as cultured primary human hepatocytes expressing the respective proteins (genotyped as TT , TC and CC ). The T94A substitution did not alter or only slightly altered L‐ FABP binding affinities for saturated, monounsaturated or polyunsaturated long chain fatty acids, nor did it change the affinity for intermediates of triglyceride synthesis. Nevertheless, the T94A substitution markedly altered the secondary structural response of L‐ FABP induced by binding long chain fatty acids or intermediates of triglyceride synthesis. Finally, the T94A substitution markedly decreased the levels of induction of peroxisome proliferator‐activated receptor α‐regulated proteins such as L‐ FABP , fatty acid transport protein 5 and peroxisome proliferator‐activated receptor α itself meditated by the polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid in cultured primary human hepatocytes. Thus, although the T94A substitution did not alter the affinity of human L‐ FABP for long chain fatty acids, it significantly altered human L‐ FABP structure and stability, as well as the conformational and functional response to these ligands." @default.
- W2000409509 created "2016-06-24" @default.
- W2000409509 creator A5020377023 @default.
- W2000409509 creator A5034673183 @default.
- W2000409509 creator A5046497078 @default.
- W2000409509 creator A5047010455 @default.
- W2000409509 creator A5056901612 @default.
- W2000409509 creator A5063582701 @default.
- W2000409509 creator A5080306738 @default.
- W2000409509 creator A5081214816 @default.
- W2000409509 creator A5091544616 @default.
- W2000409509 date "2014-04-07" @default.
- W2000409509 modified "2023-10-04" @default.
- W2000409509 title "Structural and functional interaction of fatty acids with human liver fatty acid-binding protein (L-FABP) T94A variant" @default.
- W2000409509 cites W1489009225 @default.
- W2000409509 cites W1520680379 @default.
- W2000409509 cites W1545230814 @default.
- W2000409509 cites W1553141492 @default.
- W2000409509 cites W1880379892 @default.
- W2000409509 cites W1954326473 @default.
- W2000409509 cites W1963534279 @default.
- W2000409509 cites W1966851729 @default.
- W2000409509 cites W1967618979 @default.
- W2000409509 cites W1970641718 @default.
- W2000409509 cites W1972744939 @default.
- W2000409509 cites W1975746533 @default.
- W2000409509 cites W1976050936 @default.
- W2000409509 cites W1979024093 @default.
- W2000409509 cites W1979383399 @default.
- W2000409509 cites W1980321222 @default.
- W2000409509 cites W1983171464 @default.
- W2000409509 cites W1985204165 @default.
- W2000409509 cites W1989961814 @default.
- W2000409509 cites W1991176640 @default.
- W2000409509 cites W1992110101 @default.
- W2000409509 cites W1996717802 @default.
- W2000409509 cites W1999359190 @default.
- W2000409509 cites W1999921068 @default.
- W2000409509 cites W2005215048 @default.
- W2000409509 cites W2009092266 @default.
- W2000409509 cites W2009361180 @default.
- W2000409509 cites W2009746612 @default.
- W2000409509 cites W2010349866 @default.
- W2000409509 cites W2015759207 @default.
- W2000409509 cites W2016992147 @default.
- W2000409509 cites W2020814081 @default.
- W2000409509 cites W2022983144 @default.
- W2000409509 cites W2024980955 @default.
- W2000409509 cites W2026544644 @default.
- W2000409509 cites W2027557878 @default.
- W2000409509 cites W2027815046 @default.
- W2000409509 cites W2031632179 @default.
- W2000409509 cites W2032234951 @default.
- W2000409509 cites W2033786341 @default.
- W2000409509 cites W2038988708 @default.
- W2000409509 cites W2039228941 @default.
- W2000409509 cites W2042457130 @default.
- W2000409509 cites W2042849118 @default.
- W2000409509 cites W2046813091 @default.
- W2000409509 cites W2049315339 @default.
- W2000409509 cites W2052378749 @default.
- W2000409509 cites W2053646374 @default.
- W2000409509 cites W2061083587 @default.
- W2000409509 cites W2066342925 @default.
- W2000409509 cites W2068210500 @default.
- W2000409509 cites W2070237777 @default.
- W2000409509 cites W2070468167 @default.
- W2000409509 cites W2071274012 @default.
- W2000409509 cites W2074965750 @default.
- W2000409509 cites W2077212752 @default.
- W2000409509 cites W2078528285 @default.
- W2000409509 cites W2079504501 @default.
- W2000409509 cites W2080025367 @default.
- W2000409509 cites W2081069038 @default.
- W2000409509 cites W2082442877 @default.
- W2000409509 cites W2082969584 @default.
- W2000409509 cites W2083721940 @default.
- W2000409509 cites W2085540020 @default.
- W2000409509 cites W2088637473 @default.
- W2000409509 cites W2089638069 @default.
- W2000409509 cites W2089658134 @default.
- W2000409509 cites W2090494577 @default.
- W2000409509 cites W2091765279 @default.
- W2000409509 cites W2093620670 @default.
- W2000409509 cites W2097647823 @default.
- W2000409509 cites W2098534934 @default.
- W2000409509 cites W2106531102 @default.
- W2000409509 cites W2107106435 @default.
- W2000409509 cites W2109030776 @default.
- W2000409509 cites W2112604895 @default.
- W2000409509 cites W2119196942 @default.
- W2000409509 cites W2120433835 @default.
- W2000409509 cites W2123830703 @default.
- W2000409509 cites W2129183443 @default.
- W2000409509 cites W2129307092 @default.
- W2000409509 cites W2132304671 @default.
- W2000409509 cites W2132408300 @default.
- W2000409509 cites W2133220184 @default.