FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000409992> ?p ?o ?g. }

• W2000409992 endingPage "1076" @default.
• W2000409992 startingPage "1076" @default.
• W2000409992 abstract "To investigate the effects of sulfated cholecystokinin octapeptide (CCK-8S) on the contractile activity of guinea-pig proximal colon.Proximal colonic smooth muscle (PCSM) strips were obtained from adult female guinea pigs and contractile response of PCSM strips was recorded using a polyphysiograph. PCSM cells were isolated by enzymatic digestion. Resting potential (RP), action potential (AP), large conductance potassium channel currents (I(BKCa)) and L-type calcium currents (I(Ca-L)) were recorded by patch-clamp techniques.(1) CCK-8S (10(-7) mol/L) enhanced the mean contractile amplitude of colonic circular muscle and longitudinal muscle (LM) strips by 56.53% + or - 11.92% (P = 0.038) and 65.93% + or - 12.98% (P = 0.019), respectively, as well as the mean frequency of LM by 31.69% + or - 13.58% (P = 0.023), which were significantly attenuated by pretreating strips with devazepide, nifedipine, iberiotoxin, thapsigargin (TG) and BAPTA-AM (BA) respectively; (2) CCK-8S (10(-7) mol/L) increased the AP amplitude by 38.6% + or - 3.2% (P = 0.015), decreased AP duration by 36.9% + or - 8.7% (P = 0.026), and depolarized the RP from -61.3 + or - 2.7 mV to -29.8 + or - 5.9 mV (P = 0.032); and (3) Compared with the normal control group, CCK-8S (10(-7) mol/L) enhanced the peak current of I(BKCa) by 18.7% + or - 2.1% (from 916 + or - 183 pA to 1088 + or - 226 pA; at +60 mV; P = 0.029), which was inhibited by respective pretreatment with iberiotoxin and devazepide. Additionally, CCK-8S (10(-7) mol/L) intensified the peak current of I(Ca-L) by 40% (from 60 + or - 8 pA to 84 + or - 11 pA; at +10 mV; P = 0.012), compared to the normal control group, which was apparently suppressed by respective pretreatment with nifedipine, devazepide, TG and BA. In the respective presence of heparin and staurosporine, CCK-8S did not significantly enhance I(BKCa) and I(Ca-L).The results suggest that CCK-8S promotes guinea-pig proximal colon contraction by CCK1 receptors, following activation of the inositol triphosphate-protein kinase C signal transduction pathway." @default.
• W2000409992 created "2016-06-24" @default.
• W2000409992 creator A5001753331 @default.
• W2000409992 creator A5020953576 @default.
• W2000409992 creator A5022083751 @default.
• W2000409992 creator A5057762207 @default.
• W2000409992 date "2010-01-01" @default.
• W2000409992 modified "2023-09-23" @default.
• W2000409992 title "Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs" @default.
• W2000409992 cites W1567448623 @default.
• W2000409992 cites W1798306231 @default.
• W2000409992 cites W1847711219 @default.
• W2000409992 cites W1855991206 @default.
• W2000409992 cites W1903127408 @default.
• W2000409992 cites W1970918222 @default.
• W2000409992 cites W1973777215 @default.
• W2000409992 cites W1976533768 @default.
• W2000409992 cites W1990400467 @default.
• W2000409992 cites W1994072964 @default.
• W2000409992 cites W2004612759 @default.
• W2000409992 cites W2009572612 @default.
• W2000409992 cites W2010055676 @default.
• W2000409992 cites W2010461078 @default.
• W2000409992 cites W2011759169 @default.
• W2000409992 cites W2014163936 @default.
• W2000409992 cites W2018314950 @default.
• W2000409992 cites W2024482138 @default.
• W2000409992 cites W2028184380 @default.
• W2000409992 cites W2028662482 @default.
• W2000409992 cites W2031402123 @default.
• W2000409992 cites W2052335898 @default.
• W2000409992 cites W2073443083 @default.
• W2000409992 cites W2076489990 @default.
• W2000409992 cites W2085292162 @default.
• W2000409992 cites W2090076189 @default.
• W2000409992 cites W2100965450 @default.
• W2000409992 cites W2119387187 @default.
• W2000409992 cites W2122054000 @default.
• W2000409992 cites W2126681559 @default.
• W2000409992 cites W2134203509 @default.
• W2000409992 cites W2153111625 @default.
• W2000409992 cites W2164872793 @default.
• W2000409992 cites W2416611297 @default.
• W2000409992 cites W2765376853 @default.
• W2000409992 doi "https://doi.org/10.3748/wjg.v16.i9.1076" @default.
• W2000409992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2835783" @default.
• W2000409992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20205277" @default.
• W2000409992 hasPublicationYear "2010" @default.
• W2000409992 type Work @default.
• W2000409992 sameAs 2000409992 @default.
• W2000409992 citedByCount "6" @default.
• W2000409992 countsByYear W20004099922013 @default.
• W2000409992 countsByYear W20004099922014 @default.
• W2000409992 countsByYear W20004099922015 @default.
• W2000409992 countsByYear W20004099922017 @default.
• W2000409992 crossrefType "journal-article" @default.
• W2000409992 hasAuthorship W2000409992A5001753331 @default.
• W2000409992 hasAuthorship W2000409992A5020953576 @default.
• W2000409992 hasAuthorship W2000409992A5022083751 @default.
• W2000409992 hasAuthorship W2000409992A5057762207 @default.
• W2000409992 hasBestOaLocation W20004099921 @default.
• W2000409992 hasConcept C126322002 @default.
• W2000409992 hasConcept C134018914 @default.
• W2000409992 hasConcept C147944092 @default.
• W2000409992 hasConcept C163415756 @default.
• W2000409992 hasConcept C185263204 @default.
• W2000409992 hasConcept C185592680 @default.
• W2000409992 hasConcept C2776050358 @default.
• W2000409992 hasConcept C2777146706 @default.
• W2000409992 hasConcept C2778815084 @default.
• W2000409992 hasConcept C2779411790 @default.
• W2000409992 hasConcept C519063684 @default.
• W2000409992 hasConcept C71924100 @default.
• W2000409992 hasConcept C83743174 @default.
• W2000409992 hasConceptScore W2000409992C126322002 @default.
• W2000409992 hasConceptScore W2000409992C134018914 @default.
• W2000409992 hasConceptScore W2000409992C147944092 @default.
• W2000409992 hasConceptScore W2000409992C163415756 @default.
• W2000409992 hasConceptScore W2000409992C185263204 @default.
• W2000409992 hasConceptScore W2000409992C185592680 @default.
• W2000409992 hasConceptScore W2000409992C2776050358 @default.
• W2000409992 hasConceptScore W2000409992C2777146706 @default.
• W2000409992 hasConceptScore W2000409992C2778815084 @default.
• W2000409992 hasConceptScore W2000409992C2779411790 @default.
• W2000409992 hasConceptScore W2000409992C519063684 @default.
• W2000409992 hasConceptScore W2000409992C71924100 @default.
• W2000409992 hasConceptScore W2000409992C83743174 @default.
• W2000409992 hasIssue "9" @default.
• W2000409992 hasLocation W20004099921 @default.
• W2000409992 hasLocation W20004099922 @default.
• W2000409992 hasLocation W20004099923 @default.
• W2000409992 hasLocation W20004099924 @default.
• W2000409992 hasOpenAccess W2000409992 @default.
• W2000409992 hasPrimaryLocation W20004099921 @default.
• W2000409992 hasRelatedWork W1979943688 @default.
• W2000409992 hasRelatedWork W2010055676 @default.
• W2000409992 hasRelatedWork W2017123222 @default.
• W2000409992 hasRelatedWork W2020507662 @default.

• next