Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000410194> ?p ?o ?g. }
- W2000410194 abstract "Recently the 3D structure of the Osaka mutant form (E22Δ) of Amyloid-β1-40 has been determined. We here compare the NMR chemical-shift with the published shifts of a brain-seeded form of wild-type Aβ and suggest that the determined mutant fold is accessible to the wild-type protein as well, with small conformational adaptations which accommodate the E22 residue missing in the Osaka mutant. In addition, we illustrate how other mutants could also conform to this model. The stabilization of the N-terminal part of the protein via an intermolecular salt bridge to Lys28 may represent a common structural motif for the mutants which are related to early-onset Alzheimer disease. This feature might connect to the observed increased toxicity of the mutant forms compared to wild-type Aβ1-40, where the salt bridge involving Lys28 is intramolecular." @default.
- W2000410194 created "2016-06-24" @default.
- W2000410194 creator A5004707292 @default.
- W2000410194 creator A5065491255 @default.
- W2000410194 creator A5076009010 @default.
- W2000410194 date "2015-04-28" @default.
- W2000410194 modified "2023-10-17" @default.
- W2000410194 title "Alternative salt bridge formation in Aβ—a hallmark of early-onset Alzheimer's disease?" @default.
- W2000410194 cites W1493986974 @default.
- W2000410194 cites W1518693759 @default.
- W2000410194 cites W192124582 @default.
- W2000410194 cites W1965874864 @default.
- W2000410194 cites W1969099023 @default.
- W2000410194 cites W1982797857 @default.
- W2000410194 cites W1998048668 @default.
- W2000410194 cites W2013780997 @default.
- W2000410194 cites W2017284646 @default.
- W2000410194 cites W2024473468 @default.
- W2000410194 cites W2024895952 @default.
- W2000410194 cites W2027419460 @default.
- W2000410194 cites W2029695041 @default.
- W2000410194 cites W2030325989 @default.
- W2000410194 cites W2034951782 @default.
- W2000410194 cites W2043642345 @default.
- W2000410194 cites W2058621419 @default.
- W2000410194 cites W2063272219 @default.
- W2000410194 cites W2067214887 @default.
- W2000410194 cites W2072613948 @default.
- W2000410194 cites W2076453964 @default.
- W2000410194 cites W2077808902 @default.
- W2000410194 cites W2080225612 @default.
- W2000410194 cites W2081855136 @default.
- W2000410194 cites W2081990092 @default.
- W2000410194 cites W2098022922 @default.
- W2000410194 cites W2103440561 @default.
- W2000410194 cites W2120434191 @default.
- W2000410194 cites W2139818289 @default.
- W2000410194 cites W2147358651 @default.
- W2000410194 cites W2148521301 @default.
- W2000410194 cites W2149060580 @default.
- W2000410194 cites W2162741488 @default.
- W2000410194 cites W2171495114 @default.
- W2000410194 cites W2319217996 @default.
- W2000410194 cites W4211121722 @default.
- W2000410194 doi "https://doi.org/10.3389/fmolb.2015.00014" @default.
- W2000410194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4429654" @default.
- W2000410194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25988181" @default.
- W2000410194 hasPublicationYear "2015" @default.
- W2000410194 type Work @default.
- W2000410194 sameAs 2000410194 @default.
- W2000410194 citedByCount "16" @default.
- W2000410194 countsByYear W20004101942015 @default.
- W2000410194 countsByYear W20004101942016 @default.
- W2000410194 countsByYear W20004101942017 @default.
- W2000410194 countsByYear W20004101942018 @default.
- W2000410194 countsByYear W20004101942020 @default.
- W2000410194 countsByYear W20004101942021 @default.
- W2000410194 countsByYear W20004101942022 @default.
- W2000410194 crossrefType "journal-article" @default.
- W2000410194 hasAuthorship W2000410194A5004707292 @default.
- W2000410194 hasAuthorship W2000410194A5065491255 @default.
- W2000410194 hasAuthorship W2000410194A5076009010 @default.
- W2000410194 hasBestOaLocation W20004101941 @default.
- W2000410194 hasConcept C104317684 @default.
- W2000410194 hasConcept C12554922 @default.
- W2000410194 hasConcept C126322002 @default.
- W2000410194 hasConcept C143065580 @default.
- W2000410194 hasConcept C179104552 @default.
- W2000410194 hasConcept C185592680 @default.
- W2000410194 hasConcept C207583985 @default.
- W2000410194 hasConcept C2777633098 @default.
- W2000410194 hasConcept C2779134260 @default.
- W2000410194 hasConcept C2781338088 @default.
- W2000410194 hasConcept C30765947 @default.
- W2000410194 hasConcept C502032728 @default.
- W2000410194 hasConcept C55493867 @default.
- W2000410194 hasConcept C71240020 @default.
- W2000410194 hasConcept C71924100 @default.
- W2000410194 hasConcept C75079739 @default.
- W2000410194 hasConcept C86803240 @default.
- W2000410194 hasConceptScore W2000410194C104317684 @default.
- W2000410194 hasConceptScore W2000410194C12554922 @default.
- W2000410194 hasConceptScore W2000410194C126322002 @default.
- W2000410194 hasConceptScore W2000410194C143065580 @default.
- W2000410194 hasConceptScore W2000410194C179104552 @default.
- W2000410194 hasConceptScore W2000410194C185592680 @default.
- W2000410194 hasConceptScore W2000410194C207583985 @default.
- W2000410194 hasConceptScore W2000410194C2777633098 @default.
- W2000410194 hasConceptScore W2000410194C2779134260 @default.
- W2000410194 hasConceptScore W2000410194C2781338088 @default.
- W2000410194 hasConceptScore W2000410194C30765947 @default.
- W2000410194 hasConceptScore W2000410194C502032728 @default.
- W2000410194 hasConceptScore W2000410194C55493867 @default.
- W2000410194 hasConceptScore W2000410194C71240020 @default.
- W2000410194 hasConceptScore W2000410194C71924100 @default.
- W2000410194 hasConceptScore W2000410194C75079739 @default.
- W2000410194 hasConceptScore W2000410194C86803240 @default.
- W2000410194 hasLocation W20004101941 @default.
- W2000410194 hasLocation W20004101942 @default.
- W2000410194 hasLocation W20004101943 @default.