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• W2000410789 abstract "Transfection of sense cDNA of N ‐acetylglucosaminyltransferase V (GnTV) into H7721 human hepatocellular carcinoma cells resulted in the decreased expression of surface sialyl Lewis X (SLe x ), a sialylated fucose‐containing antigen. The enzymatic mechanisms were speculated to be the concomitantly decreased expression of α1,3‐fucosyltransferase (FucT)‐III, ‐VI, ‐VII and the branching enzyme of O ‐glycans, core 2‐β1,6‐ N ‐acetylglucosaminyltransferase (C2GnT)‐I, ‐II. These two glycosyltransferase families were suggested to be the key enzymes in the synthesis of SLe x . The expression of α2,3‐sialyltransferase (ST3)‐IV, but not ST3‐I, ‐II and ‐III was elevated by sense GnTV. However, it did not cause the increase of SLe x synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above‐mentioned SLe x and glycosyltransferases as the sense GnTV." @default.
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• W2000410789 date "2004-03-01" @default.
• W2000410789 modified "2023-10-13" @default.
• W2000410789 title "Effect of <i>N</i>‐acetylglucosaminyltransferase V on the expressions of other glycosyltransferases" @default.
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• W2000410789 doi "https://doi.org/10.1016/s0014-5793(04)00188-7" @default.
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