Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000411419> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000411419 endingPage "685" @default.
- W2000411419 startingPage "681" @default.
- W2000411419 abstract "The role of the amino acid at position α38 in haemoglobin has been probed using site-directed mutagenesis. When the Thr residue at position α38 (which is totally conserved in all mammals) is changed to a Gln, the equilibrium properties of the protein are significantly altered. Equilibrium and kinetic data show that the R-state properties of the protein are essentially unaffected by the mutation whilst the allosteric equilibrium and T-state properties are changed. Mutation of the naturally occurring Gln38 of the human embryonic haemoglobin ζ-chain (the only known non-Thr containing globin) to a Thr residue shows the converse change in properties produced by the adult mutation, although in this case the situation is complicated by significant chain heterogeneity in the T state. An extension of the two-state model of co-operativity is presented to describe quantitatively the equilibrium ligand binding in the presence of T-state chain heterogeneity. A molecular model is described in which the putative interaction of αGln38 and βTyr145 is identified which make a significant contribution to the previously reported unusual ligand-binding properties of the ζ-chain containing human embryonic haemoglobins." @default.
- W2000411419 created "2016-06-24" @default.
- W2000411419 creator A5025848770 @default.
- W2000411419 creator A5033932781 @default.
- W2000411419 creator A5045601187 @default.
- W2000411419 creator A5056681167 @default.
- W2000411419 date "1999-10-25" @default.
- W2000411419 modified "2023-09-24" @default.
- W2000411419 title "The role of amino acid α38 in the control of oxygen binding to human adult and embryonic haemoglobin Portland" @default.
- W2000411419 cites W1554994168 @default.
- W2000411419 cites W1575936937 @default.
- W2000411419 cites W194402373 @default.
- W2000411419 cites W1965381203 @default.
- W2000411419 cites W1966789368 @default.
- W2000411419 cites W1975900955 @default.
- W2000411419 cites W1978562107 @default.
- W2000411419 cites W1997440251 @default.
- W2000411419 cites W1997875905 @default.
- W2000411419 cites W2004194157 @default.
- W2000411419 cites W2009410566 @default.
- W2000411419 cites W2018252877 @default.
- W2000411419 cites W2033007215 @default.
- W2000411419 cites W2033870629 @default.
- W2000411419 cites W2044672033 @default.
- W2000411419 cites W2057844928 @default.
- W2000411419 cites W2116208680 @default.
- W2000411419 cites W2207154394 @default.
- W2000411419 cites W2336573491 @default.
- W2000411419 cites W2406264139 @default.
- W2000411419 doi "https://doi.org/10.1042/bj3430681" @default.
- W2000411419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220602" @default.
- W2000411419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10527949" @default.
- W2000411419 hasPublicationYear "1999" @default.
- W2000411419 type Work @default.
- W2000411419 sameAs 2000411419 @default.
- W2000411419 citedByCount "4" @default.
- W2000411419 countsByYear W20004114192017 @default.
- W2000411419 crossrefType "journal-article" @default.
- W2000411419 hasAuthorship W2000411419A5025848770 @default.
- W2000411419 hasAuthorship W2000411419A5033932781 @default.
- W2000411419 hasAuthorship W2000411419A5045601187 @default.
- W2000411419 hasAuthorship W2000411419A5056681167 @default.
- W2000411419 hasBestOaLocation W20004114192 @default.
- W2000411419 hasConcept C104317684 @default.
- W2000411419 hasConcept C107824862 @default.
- W2000411419 hasConcept C116569031 @default.
- W2000411419 hasConcept C12554922 @default.
- W2000411419 hasConcept C125996951 @default.
- W2000411419 hasConcept C166342909 @default.
- W2000411419 hasConcept C170493617 @default.
- W2000411419 hasConcept C185592680 @default.
- W2000411419 hasConcept C2778917026 @default.
- W2000411419 hasConcept C2781338088 @default.
- W2000411419 hasConcept C501734568 @default.
- W2000411419 hasConcept C515207424 @default.
- W2000411419 hasConcept C55493867 @default.
- W2000411419 hasConcept C71240020 @default.
- W2000411419 hasConcept C86803240 @default.
- W2000411419 hasConceptScore W2000411419C104317684 @default.
- W2000411419 hasConceptScore W2000411419C107824862 @default.
- W2000411419 hasConceptScore W2000411419C116569031 @default.
- W2000411419 hasConceptScore W2000411419C12554922 @default.
- W2000411419 hasConceptScore W2000411419C125996951 @default.
- W2000411419 hasConceptScore W2000411419C166342909 @default.
- W2000411419 hasConceptScore W2000411419C170493617 @default.
- W2000411419 hasConceptScore W2000411419C185592680 @default.
- W2000411419 hasConceptScore W2000411419C2778917026 @default.
- W2000411419 hasConceptScore W2000411419C2781338088 @default.
- W2000411419 hasConceptScore W2000411419C501734568 @default.
- W2000411419 hasConceptScore W2000411419C515207424 @default.
- W2000411419 hasConceptScore W2000411419C55493867 @default.
- W2000411419 hasConceptScore W2000411419C71240020 @default.
- W2000411419 hasConceptScore W2000411419C86803240 @default.
- W2000411419 hasIssue "3" @default.
- W2000411419 hasLocation W20004114191 @default.
- W2000411419 hasLocation W20004114192 @default.
- W2000411419 hasLocation W20004114193 @default.
- W2000411419 hasOpenAccess W2000411419 @default.
- W2000411419 hasPrimaryLocation W20004114191 @default.
- W2000411419 hasRelatedWork W1987023906 @default.
- W2000411419 hasRelatedWork W2003871809 @default.
- W2000411419 hasRelatedWork W2016987949 @default.
- W2000411419 hasRelatedWork W2075370468 @default.
- W2000411419 hasRelatedWork W2128378535 @default.
- W2000411419 hasRelatedWork W2161049438 @default.
- W2000411419 hasRelatedWork W2277095979 @default.
- W2000411419 hasRelatedWork W2361125336 @default.
- W2000411419 hasRelatedWork W2419648357 @default.
- W2000411419 hasRelatedWork W4252819749 @default.
- W2000411419 hasVolume "343" @default.
- W2000411419 isParatext "false" @default.
- W2000411419 isRetracted "false" @default.
- W2000411419 magId "2000411419" @default.
- W2000411419 workType "article" @default.