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• W2000412578 abstract "1. The influence of the transverse-tubular (T-) system Cl- conductance on membrane excitability in skeletal muscle fibres of toad and rat was examined because of conflicting conclusions of previous studies on Cl- conductance. A mechanically skinned fibre preparation was used that permitted investigation of Ca2+ release via the normal T-system voltage-sensor mechanism after complete removal of the surface membrane, which thereby allowed estimation of the T-system potential from force measurements. 2. When a skinned fibre was bathed in a high-[K+] solution, the sealed T-system became polarized and could be rapidly depolarized by replacing the K+ with Na+, thereby eliciting Ca2+ release from the sarcoplasmic reticulum. In rat skinned fibres, addition of 20 mM Cl- to the 'myoplasm' (i.e. bathing solution) partially depolarized the T-system, inducing Ca2+ release and subsequent voltage-sensor inactivation. These effects were completely abolished with 100 microM of the Cl- channel blocker 9-anthracene carboxylic acid (9-AC). Voltage-sensor inactivation increased in a graded manner over the range 3-20 mM myoplasmic Cl-. 3. In toad fibres, voltage-sensor inactivation was only detectable at > 10 mM myoplasmic Cl-, and 20 mM Cl- was only able to depolarize the T-system sufficiently to trigger Ca2+ release if the myoplasmic [K+] was reduced by 50 %. In toad fibres, 100 microM 9-AC caused little if any block of the T-system Cl- conductance. 4. It was also found that when skinned fibres were obtained from muscles that had been bathed in a zero Cl- extracellular solution, the initial Na+ substitutions were more effective at depolarizing the T-system. This is consistent with Cl- trapped in the sealed T-system exerting a polarizing effect on T-system potential. 5. These results unequivocally demonstrate that there is a large 9-AC-sensitive Cl- conductance in the T-system of rat fibres, and a smaller, though still appreciable, Cl- conductance in the T-system of toad fibres, which is relatively insensitive to 9-AC. The results are important for understanding the basis of the Cl- channel aberration in myotonia." @default.
• W2000412578 created "2016-06-24" @default.
• W2000412578 creator A5080330787 @default.
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• W2000412578 date "1998-06-01" @default.
• W2000412578 modified "2023-10-15" @default.
• W2000412578 title "Effect of transverse-tubular chloride conductance on excitability in skinned skeletal muscle fibres of rat and toad" @default.
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• W2000412578 doi "https://doi.org/10.1111/j.1469-7793.1998.551bn.x" @default.
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