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• W2000413249 abstract "Intracellular and bipolar surface electrodes were used to record electrical activity from isolated hearts of human fetuses at midgestation (17–24 weeks). Action potential characteristics for cells in the sinus node, the atrium, the AV-node, and the ventricle are described. Diastolic depolarizations and subthreshold oscillations indicating latent pacemaker activity were found in arrial cells but not in ventricle cells. Resting membrane potential in ventricle cells was – 81.4 mV at 37°C and an external potassium concentration of 4 mM. With increasing external potassium concentrations, the resting membrane potential increased, within the range 8–64 mM the change was 51.2 mV per tenfold increase in potassium concentration. In 0.5 mM potassium solution, the amplitude of the resting membrane potential declined in ventricle cells and spontaneous action potentials appeared. Within the temperature range 37–19°C, a decrease in temperature increased the resting membrane potential 0.9 mV per°C. Conduction velocity in both atrium and ventricle was 0.4–0.7 mlsec. In ventricle, the conduction velocity decreased with increasing stimulation frequency within the range studied (12–240 stim./min). In atrium, the conduction velocity decreased both at frequencies above 100/min and at very low frequencies. The conduction velocity through the AV-node was approximately 0.01 m/sec and decreased with increasing stimulation frequency above 100 stim./min." @default.
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• W2000413249 date "1970-07-01" @default.
• W2000413249 modified "2023-10-16" @default.
• W2000413249 title "Excitation and Impulse Conduction in the Human Fetal Heart" @default.
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• W2000413249 doi "https://doi.org/10.1111/j.1748-1716.1970.tb04731.x" @default.
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