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• W2000413429 abstract "GM-CSF, stimulates tissue macrophages, causing an increased abundance in the skin. It is also speculated that high levels of G-CSF produce many in ammatory cytokines in the skin, which leads to a greater monocular cell in® ltration in this tissue (4, 5). In the literature, we found 4 cases with predominant mononuclear cell in® ltration in cutaneous reactions associated with the use of G-CSF (5, 6), just as in our patient. There were 2 cases of cancer involving internal organs (5, 6), a case of acute leukemia (5), and a case of Hodgkin’s disease (5). Most of the cutaneous reactions were erythematous plaques. The appearance of the cutaneous reactions started 13± 42 days after the use of G-CSF. Histologically, cutaneous reactions showed dominant perivascular lymphohistiocytic in® ltration with few neutrophils. The majority of in® ltrated cells were Fig. 2. Positive immunostaining with CD68 in the dermis showing CD68-positive in all biopsied cases (5, 6). Our report adds to perivascular and perifollicular mononuclear cell in® ltrations in the the body of evidence showing that administration of G-CSF dermis ( 3 40). induces a cutaneous reaction that histopathologically shows a CD68-positive mononuclear cell in® ltration into the skin. 3. Jain KK. Cutaneous vasculitis associated with granulocyte colonystimulating factor. J Am Acad Dermatol 1994; 31: 213± 215. 4. Paul C, Giachetti S, Calvo F. Cutaneous eŒects of granulocyte colony-stimulating factor in healthy volunteers. Arch Dermatol REFERENCES 1998; 134: 111± 112. 5. Glass L, Fotopoulos T, Messina L. A generalized cutaneous 1. Johnson ML, Grimwood RE. Leukocyte colony-stimulating reaction induced by granulocyte colony-stimulating factor. J Am factors: a review of associated neutrophilic dermatoses and vasAcad Dermatol 1996; 34: 455± 459. culitides. Arch Dermatol 1994; 130: 77± 81. 6. Farina MC, Requena L, Domine M, Soriano ML, Estevez L, 2. Ostlere LS, Harris D, Prentice HG, Rustin MH. Widespread Barat A. Histopathology of cutaneous reaction to granulocyte folliculitis induced by human granulocyte-colony-stimulatingfactor colony-stimulating factor: another pseudomalignancy. J Cutan Pathol 1998; 25: 559± 562. therapy. Br J Dermatol 1992; 127: 193± 194." @default.
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• W2000413429 date "2001-12-01" @default.
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• W2000413429 title "Constitutional Pompholyx Eczema Complicated by Secondary Lymphoedema" @default.
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• W2000413429 doi "https://doi.org/10.1080/000155501317208453" @default.
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