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- W2000413455 abstract "Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals." @default.
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- W2000413455 date "2000-07-14" @default.
- W2000413455 modified "2023-10-10" @default.
- W2000413455 title "Role of the Mouse <i>ank</i> Gene in Control of Tissue Calcification and Arthritis" @default.
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- W2000413455 doi "https://doi.org/10.1126/science.289.5477.265" @default.
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